Analysis of MSX1, RYK, NFκB p65, and CCL4 Proteins and

Mārtiņš Vaivads, Alise Elizabete Rone, Māra Pilmane

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mārtiņš VaivadsInstitute of Anatomy and Anthropology, Rīga Stradiņš University, Krovalda Boulevard 9, LV-1010 Riga, Latvia.ORCID 0000-0001-8282-9733

Alise Elizabete RoneInstitute of Anatomy and Anthropology, Rīga Stradiņš University, Krovalda Boulevard 9, LV-1010 Riga, Latvia.ORCID 0009-0001-2104-5510

Māra PilmaneInstitute of Anatomy and Anthropology, Rīga Stradiņš University, Krovalda Boulevard 9, LV-1010 Riga, Latvia.ORCID 0000-0001-9804-4666

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cleft lip morphopathogenesis is a complicated process involving multiple genes and proteins. Certain factors like muscle segment homeobox 1 (MSX1) and 2 (MSX2) as well as receptor-like tyrosine kinase (RYK) are important during lip embryogenesis, while others like nuclear factor kappa-B protein 65 (NFκB p65), C-C motif chemokine ligand 4 (CCL4), and pentraxin 3 (PTX3) regulate local inflammation and immunomodulation. The exact role of these factors in human cleft morphopathogenesis remains uncertain and limits the opportunity to improve cleft treatment and possible prophylaxis. Immunohistochemistry (IHC) for MSX1, RYK, NFκB p65, and CCL4 proteins and chromogenic in situ hybridization (CISH) for

Indexed as

Cleft LipC-Reactive ProteinMSX1 Transcription FactorSerum Amyloid P-ComponentTranscription Factor RelAFemaleHomeodomain ProteinsHumansInfantMalePentraxinsC-Reactive ProteinHomeodomain ProteinsMSX1 protein, humanMSX1 Transcription FactorMSX2 proteinPentraxinsRELA protein, humanSerum Amyloid P-ComponentTranscription Factor RelACCL4CISHcleft lipIHCMSX1MSX2NFκB p65PTX3RYK

Identifiers

PMID41226636

DOI10.3390/ijms262110599

PMCPMC12607811

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.