Targeted Analysis of Placental Steroid Hormones in Relation to Maternal Tobacco Smoke Exposure: Early Markers Relevant to DOHaD (Developmental Origins of Health and Disease).

Alicja Kotłowska, Sebastian Fitzek, Rafał Stettner, Sylwia Narkowicz, Bogumiła Kiełbratowska, Piotr Szefer

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Alicja KotłowskaDepartment of Clinical and Experimental Endocrinology, Faculty of Health Sciences, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.ORCID 0000-0001-5646-3555

Sebastian FitzekFaculty of Communication and Public Relations, National University of Political Studies and Public Administration, 012104 Bucharest, Romania.ORCID 0000-0001-6454-7820

Rafał StettnerClinical Department of Operative Gynecology and Gynecologic Oncology, University Hospital 4 Dr. K. Jaczewskiego 8, 20-090 Lublin, Poland.

Sylwia NarkowiczDepartment of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology, 11/12 Narutowicza St., 80-233 Gdańsk, Poland.

Bogumiła KiełbratowskaDepartment of Obstetrics, Faculty of Medical Sciences, Medical University of Gdańsk, Dębinki 7, 80-210 Gdańsk, Poland.

Piotr SzeferDepartment of Food Sciences, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal tobacco smoke exposure is associated with impaired fetal growth and long-term disease risk (DOHaD, Developmental Origins of Health and Disease). Whether placental steroid hormones are independently altered remains a matter of debate. We quantified six placental steroids (estradiol, estriol, estrone, progesterone, testosterone, and pregnanediol) using HPLC-Corona CAD in 70 deliveries (C = 30; PS = 20; AS = 20). Distributional differences were assessed with Kruskal-Wallis and pairwise Mann-Whitney tests with Benjamini-Hochberg (BH) control. Adjusted associations used log-linear OLS with HC3 robust SE: Model A (gestational age, maternal BMI, newborn sex) and Model B (Model A + birth weight), reported as percent change vs. controls, computed as (exp(β) - 1) × 100 with 95% CI. Secondary analyses tested (i) multiclass logistic classification of C/PS/AS from the steroid panel (5-fold stratified CV) and (ii) prediction of birth weight (OLS and 2-component PLS). All six steroids differed by group (BH-adjusted p ranging from 9.18 × 10

Indexed as

Maternal ExposurePlacentaPlacental HormonesPrenatal Exposure Delayed EffectsSteroidsTobacco Smoke PollutionAdultBiomarkersBirth WeightDevelopmental Origins of Health and DiseaseEstriolFemaleHumansInfant, NewbornMalePregnancyBiomarkersEstriolPlacental HormonesSteroidsTobacco Smoke Pollutiondevelopmental originsDOHaDendocrine disruptionHPLC–Corona CADpassive smokingplacentasteroid hormonestobacco smoke

Identifiers

PMID41226586

DOI10.3390/ijms262110548

PMCPMC12609261

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.