Evidence map›Paper›PMID 41226570›Full record

ArticleInternational journal of molecular sciences2025

Lower Thyroid Function and Higher Plasma Choline: Effect Modification by Metabolic Dysfunction-Associated Steatotic Liver Disease.

Adrian Post, Margery A Connelly, Stephan J L Bakker, Robin P F Dullaart

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Adrian PostDepartment of Nephrology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8645-1627
Margery A ConnellyLabcorp, Morrisville, NC 27560, USA.ORCID 0000-0002-3917-592X
Stephan J L BakkerDepartment of Nephrology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3356-6791
Robin P F DullaartDepartment of Endocrinology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-3844-5254

Funding

The Dutch Kidney Foundation funded the infrastructure of the PREVEND program from 1997 to 2003 Grant E.033The Netherlands Heart Foundation grant 2001-005
6 · The paper itself

Abstract

Evidence is accumulating that there is a bidirectional relationship between thyroid function and the gut microbiome. We assessed associations of gut microbiome-derived circulating metabolites, choline, trimethylamine N-oxide (TMAO), and betaine with thyroid function status. Among 4771 euthyroid participants of the community-dwelling PREVEND cohort study (thyroid stimulating hormone (TSH), free thyroxine, and free triiodothyronine levels within the reference range; no use of thyroid function altering medication), associations of TSH (higher levels indicating low-normal thyroid function) with choline, TMAO, and betaine (determined by nuclear magnetic resonance spectroscopy) were assessed. Plasma choline varied by TSH category with the highest values observed in the highest TSH quartile (

Indexed as

CholineFatty LiverThyroid GlandAdultAgedBetaineCohort StudiesFemaleGastrointestinal MicrobiomeHumansMaleMethylaminesMiddle AgedThyroid Function TestsThyrotropinThyroxineBetaineCholineMethylaminesThyrotropinThyroxinetrimethyloxaminecholinegeneral populationthyroid functionTMAO

Identifiers

PMID41226570
PMCPMC12608030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.