Evidence map›Paper›PMID 41226545›Full record

ArticleInternational journal of molecular sciences2025

Analysis of the Circulating miRNome Expression Profile in Saliva Samples After Neoadjuvant Chemoradiotherapy in a Rectal Cancer Study Population Using Next-Generation Sequencing.

Kristóf Gál, Péter Dávid, Melinda Paholcsek, Márton Barabás, Endre Szilágyi, Krisztina Balogh, Dóra Solymosi, Szidónia Miklós, Johanna Mikáczó, Krisztina Trási and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kristóf GálDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-8745-7657
Péter DávidFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-6451-1200
Melinda PaholcsekFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.
Márton BarabásDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Endre SzilágyiFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.
Krisztina BaloghDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Dóra SolymosiDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Szidónia MiklósDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Johanna MikáczóDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Krisztina TrásiDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Emese CsikiDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Mihály SimonDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
Péter FausztFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-1192-9646
Szilárd PóliskaDepartment of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-9722-251X
Judit RemenyikFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0003-1321-0907
Árpád KovácsDepartment of Oncoradiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.ORCID 0000-0002-8469-5764
Emese Szilágyi-TolnaiFaculty of Agricultural and Food Sciences and Environmental Management, Complex Systems and Microbiome-Innovations Centre, University of Debrecen, 4032 Debrecen, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dysregulated microRNAs (miRNAs) have been implicated in the pathogenesis and progression of rectal adenocarcinoma. In this study, we aimed to identify miRNA alterations associated with the efficacy of neoadjuvant chemoradiotherapy in rectal cancer patients. High-throughput small RNA sequencing was performed to assess salivary miRNA expression profiles in 31 participants (11 rectal adenocarcinoma patients and 20 healthy volunteers). Paired saliva samples were collected from patients before and after chemoradiation. Tumor regression was classified according to the modified Ryan scheme into responders (tumor regression grade [TRG] 1-2,

Indexed as

AdenocarcinomaCirculating MicroRNAMicroRNAsRectal NeoplasmsSalivaTranscriptomeAdultAgedBiomarkers, TumorChemoradiotherapyFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHigh-Throughput Nucleotide SequencingHumansMaleBiomarkers, TumorCirculating MicroRNAMicroRNAsmiRNAsneoadjuvant concurrent chemoradiotherapyrectal cancertumor regression grade

Identifiers

PMID41226545
PMCPMC12610449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.