Evidence map›Paper›PMID 41226524›Full record

ReviewInternational journal of molecular sciences2025

Dissecting the Genetic Contribution of Tooth Agenesis.

Antonio Fallea, Mirella Vinci, Simona L'Episcopo, Massimiliano Bartolone, Antonino Musumeci, Alda Ragalmuto, Simone Treccarichi, Francesco Calì

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Antonio FalleaOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0002-1927-9465
Mirella VinciOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0003-3026-8510
Simona L'EpiscopoOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0009-0001-9399-6104
Massimiliano BartoloneOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0009-0009-6715-8869
Antonino MusumeciOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0002-8999-3365
Alda RagalmutoOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0002-7399-964X
Simone TreccarichiOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0001-5631-9991
Francesco CalìOasi Research Institute-IRCCS, 94018 Troina, Italy.ORCID 0000-0001-8667-8223

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tooth agenesis (TA), the congenital absence of one or more teeth, is the most common manifestation of defective dental morphogenesis in humans. TA can occur as an isolated (non-syndromic) condition or as part of a broader syndromic presentation. In this review, we analyzed a total of 73 manuscripts to provide a comprehensive update on the genetic landscape of TA. To investigate the genes, variants, and associated phenotypes, we reviewed data from curated databases including Human Phenotype Ontology (HPO), OMIM, ClinVar and MalaCards. Based on the current evidence, the genes most frequently implicated in TA are

Indexed as

AnodontiaGenetic Predisposition to DiseaseHumansMSX1 Transcription FactorPAX9 Transcription FactorPhenotypeSignal TransductionMSX1 protein, humanMSX1 Transcription FactorPAX9 Transcription Factoranodontiadental agenesishypodontianext generation sequencingodontogenesisoligodontia

Identifiers

PMID41226524
PMCPMC12609137

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.