Evidence map›Paper›PMID 41226515›Full record

ReviewInternational journal of molecular sciences2025

Bone Metabolic Changes and Osteoporosis During Pregnancy and Lactation: A View from Dental Medicine.

Mai Nishiura, Haruhisa Watanabe, Atsuko Nakanishi-Kimura, Marie Hoshi-Numahata, Shinnosuke Nishimoto, Fumi Ueno, Riyu Koguchi, Ryutaro Takemoto, Yusuke Kurakane, Lang Bao and 1 more

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mai NishiuraDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Haruhisa WatanabeDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.ORCID 0000-0001-6741-1291
Atsuko Nakanishi-KimuraDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Marie Hoshi-NumahataDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.ORCID 0009-0003-4796-2346
Shinnosuke NishimotoDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Fumi UenoDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Riyu KoguchiDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Ryutaro TakemotoDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Yusuke KurakaneDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Lang BaoDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.
Tadahiro IimuraDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, Sapporo 060-8586, Japan.ORCID 0000-0002-1431-0689

Funding

JST SPRING JPMJSP2119 to M.N., H.W., A.N-K., M.H-N., S.N., F.U., and R.K.the Japan Society for the Promotion of Science (JSPS KAKENHI) grant numbers 25K24119 to M.N., 25K20391 to H.W., 24K20047 to A.N-K., 24K23572 to M.H-N., and 25K22680, 24KK0165 and 23K18347 to T.I.
6 · The paper itself

Abstract

Pregnancy- and lactation-associated osteoporosis (PLO) is receiving increasing attention. During pregnancy and lactation, bone metabolism is dramatically changed to supply minerals to the fetus and infant, which is a major cause of PLO. Weaning of lactation is clinically a primary choice to treat lactation-induced osteoporosis since breastfeeding is a key regulator of the pathophysiology during lactation. However, breastfeeding is beneficial to the physical and mental development of infants. We also discuss the beneficial effects of breastfeeding on the oral and maxillofacial development of infants. Pharmacological treatment of PLO is also discussed. This review also discusses how dynamic regulatory changes in bone metabolism during pregnancy and lactation affect homeostasis of the temporomandibular joint (TMJ) and alveolar bone in mothers, from the perspectives of TMJ diseases and orthodontic treatment.

Indexed as

Bone and BonesLactationOsteoporosisPregnancy ComplicationsAnimalsBreast FeedingFemaleHumansPregnancybone metabolismoral developmentorthodontic treatmentPLOtemporomandibular joint

Identifiers

PMID41226515
PMCPMC12609550

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.