Evidence map›Paper›PMID 41226514›Full record

ArticleInternational journal of molecular sciences2025

In Vitro Analysis of the Dynamic Role of the Bacterial Virulence Factors in Skin Wound Healing.

Ayat S Hammad, Sarah H Zahedy, Shatha S Elqasass, Sawsan Sudqi Said, Abdelrahman M Elgamal, Nouf N Mahmoud, Maha Al-Asmakh

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayat S HammadDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Sarah H ZahedyDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Shatha S ElqasassDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Sawsan Sudqi SaidDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.ORCID 0000-0002-0357-7839
Abdelrahman M ElgamalDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.ORCID 0000-0002-9542-3107
Nouf N MahmoudDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.
Maha Al-AsmakhDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, Qatar.

Funding

Qatar University QU Student Grant: (QUST -1-CHS-2024-1813) and (QU Grant: QUPD-CHS-23-24-563
6 · The paper itself

Abstract

The skin acts as a primary barrier against environmental insults and maintains homeostasis. Injury initiates a wound healing cascade of hemostasis, inflammation, proliferation, and remodeling. In chronic wounds, persistent microbial colonization and inflammation disrupt this process, with bacterial virulence factors acting as key drivers. While the microbiome's role in chronic wounds is recognized, the effects of individual virulence factors on acute repair remain unclear. Therefore, this study investigated the differential effects of virulence factors derived from five skin-associated bacterial species on acute wound healing dynamics. In this context, virulence factors from

Indexed as

BacteriaSkinVirulence FactorsWound HealingCell LineCell SurvivalEnterococcus faecalisFibroblastsHumansPseudomonas aeruginosaStaphylococcus aureusStreptococcus pyogenesVirulence Factorsbacteriainflammatory markersskinvirulence factorswound healing

Identifiers

PMID41226514
PMCPMC12607956

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.