Evidence map›Paper›PMID 41226506›Full record

ArticleInternational journal of molecular sciences2025

Accumulation of Lymphoid Progenitors with Defective B Cell Differentiation and of Putative Natural Killer Progenitors in Aging Human Bone Marrow.

Laura Poisa-Beiro, Jonathan J M Landry, Aleksandr Cherdintsev, Michael Kardorff, Volker Eckstein, Laura Villacorta, Judith Zaugg, Anne-Claude Gavin, Vladimir Benes, Simon Raffel and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Poisa-BeiroDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.
Jonathan J M LandryGenomics Core Facility, European Molecular Biology Laboratories (EMBL), 69117 Heidelberg, Germany.ORCID 0000-0003-2262-9099
Aleksandr CherdintsevDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.
Michael KardorffDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.
Volker EcksteinDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.
Laura VillacortaGenomics Core Facility, European Molecular Biology Laboratories (EMBL), 69117 Heidelberg, Germany.
Judith ZauggMolecular Medicine Partnership Unit, EMBL & Heidelberg University, 69117 Heidelberg, Germany.
Anne-Claude GavinDepartment of Cell Physiology and Metabolism, University of Geneva, CH-1211 Geneva, Switzerland.ORCID 0000-0003-4917-2340
Vladimir BenesGenomics Core Facility, European Molecular Biology Laboratories (EMBL), 69117 Heidelberg, Germany.ORCID 0000-0002-0352-2547
Simon RaffelDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.
Anthony D HoDepartment of Medicine V, Heidelberg University, 69120 Heidelberg, Germany.ORCID 0000-0002-1656-0833

Funding

Deutsche Forschungsgemeinschaft CRC873Deutsche Forschungsgemeinschaft HO914/10Deutsche Forschungsgemeinschaft RA3166/1-1Deutsche Forschungsgemeinschaft RA3166/3-1European Union FP7-306240 SyStemAge
6 · The paper itself

Abstract

In animal models, elimination of the senescent cells in the hematopoietic stem cells (HSCs) compartment leads to the rejuvenation of hematopoiesis. Whether this treatment principle can be applied to the human system remains controversial. The identification of senescent cells in human bone marrow poses another major challenge. To address these questions, we have studied hematopoietic stem and progenitor cells (HSPCs, CD34

Indexed as

B-LymphocytesBone MarrowCellular SenescenceHematopoiesisKiller Cells, NaturalLymphoid Progenitor CellsAdultAgedAgingBiomarkersDatasets as TopicHumansMiddle AgedSingle-Cell Gene Expression AnalysisYoung AdultBiomarkersaginghematopoietic stem and progenitor cellshuman bone marrowimmunosenescencelymphoid compartmentmemory-like NK cellsnatural killer progenitorssenescencesenolysis

Identifiers

PMID41226506
PMCPMC12609476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.