ReviewInternational journal of molecular sciences2025
Ventilator-Associated Lung Injury: Pathophysiology, Prevention, and Emerging Therapeutic Strategies.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Dexmedetomidine reduces pulmonary complications in older patients undergoing abdominal laparoscopic surgery: a prospective, single-blinded, randomized controlled trial.BMC anesthesiology · 2026Trial
- Article
- Clinical Outcomes and Hospitalization Cost of Minimally Invasive Surfactant Therapy vs. INSURE (Intubate-Surfactant-Extubate) Method in Neonates with Respiratory Distress Syndrome.Indian journal of pediatrics · 2026Article
- Extracellular Vesicles from Bronchoalveolar Lavage Fluid Indicate Early Biomarker Potential and Differentiate Local Lung Injury in a Porcine Model of Asymmetric Acute Lung Injury.International journal of molecular sciences · 2026Article
- Association between tidal volume and mortality in patients without acute respiratory distress syndrome: A systematic review and meta-analysis.Biomedical reports · 2026Article
- Preoperative Inflammatory Ratios and Severe Intraoperative Hypoxemia During One-Lung Ventilation: A Prospective Observational Study.Life (Basel, Switzerland) · 2026Article
- Ventilator-Induced Lung Liquid and Alveolar Rupture.Journal of clinical medicine · 2026Article
- Progress on the mechanism of Piezo1 in mechanical ventilation-induced lung injury.Journal of thoracic disease · 2026Review
- Take a deep breath: managing the challenges of acute respiratory distress syndrome cases.Trauma surgery & acute care open · 2026Review
- Long-term impact of a quality improvement program on unplanned extubation and clinical outcomes in adult intensive care units: a 24-year single-center observational study.Frontiers in medicine · 2026Article
- Chlorine inhalation-induced ARDS treated with noninvasive ventilation and awake prone positioning: a case report.Frontiers in medicine · 2026Article
- From Alveolar Injury to Precision Perioperative Care: Integrating Molecular Biomarkers and Technology-Enabled Strategies for Prolonged Air Leak After Lung Resection.Mediators of inflammation · 2026Review
- Revisiting ventilator-induced lung injury: from mechanical power to immunometabolic interaction.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanical ventilation is a critical intervention in patients who cannot spontaneously maintain adequate oxygenation and remove carbon dioxide. However, it can also lead to severe lung injury via volutrauma, barotrauma, atelectrauma and biotrauma, and it can worsen existing lung disease such as acute respiratory distress syndrome. Ventilator-associated lung injury, the clinical manifestations of lung damage associated with mechanical ventilation, can trigger systemic inflammatory cascades that contribute to multi-organ failure. The utilization of lung-protective ventilation strategies helps to minimize further injury to the lungs during mechanical ventilation and improve survival rates. This review discusses the pathophysiology of ventilator-associated lung injury, including cellular and molecular responses, its systemic effects, risk factors, clinical presentation and diagnosis, protective strategies, and emerging therapies. It incorporates interdisciplinary advances, from novel pharmacologic and stem-cell therapies coupled with artificial intelligence and machine learning systems to provide a framework for the prevention of ventilator-associated lung injury that moves beyond purely mechanical considerations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.