ArticleInternational journal of molecular sciences2025
Strong Association Between MiRNA Gene Variants and Type 2 Diabetes Mellitus in a Caucasian Population.
Eleni Manthou, Xanthippi Tsekmekidou, Fotis Tsetsos, Theocharis Koufakis, Maria Grammatiki, Pantelitsa Rakintzi, Eirini Melidou, Georgios Karaliolios, Peristera Paschou, Nikolaos Papanas and 1 more
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In one paragraphArticle in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Eleni ManthouDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Xanthippi TsekmekidouDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.ORCID 0000-0003-1879-856X Fotis TsetsosDepartment of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupoli, Greece.ORCID 0000-0001-5521-846X Theocharis KoufakisSecond Propaedeutic Department of Internal Medicine, Hippokration General Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.ORCID 0000-0002-5853-1352 Maria GrammatikiDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Pantelitsa RakintziDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Eirini MelidouDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Georgios KaralioliosDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.
Peristera PaschouDepartment of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupoli, Greece.
Nikolaos PapanasDiabetes Center, Second Department of Internal Medicine, Democritus University of Thrace, 68100 Alexandroupoli, Greece.
Kalliopi KotsaDiabetes Center, First Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece.ORCID 0000-0003-2376-740X Funding
National Strategic Reference Framework (NSRF) - Research Funding Program: THALES MIS 380273
6 · The paper itselfAbstract
MicroRNAs (miRNAs), small non-coding RNAs, have emerged as promising diagnostic and prognostic biomarkers for various diseases. However, their role in the pathogenesis of type 2 diabetes mellitus (T2DM) remains insufficiently defined. This case-control study investigated associations between genetic variants in miRNA genes and susceptibility to T2DM in a Greek population. A total of 716 individuals with T2DM and 569 controls (HbA1c < 6.5% and fasting plasma glucose < 126 mg/dL) were included. Genomic DNA was extracted from whole blood and genotyped using the Illumina Infinium PsychArray platform. Polymorphisms in
Indexed as
Diabetes Mellitus, Type 2Genetic Predisposition to DiseaseMicroRNAsPolymorphism, Single NucleotideAgedCase-Control StudiesEuropean PeopleFemaleGene FrequencyGenetic Association StudiesGenotypeGreeceHumansMaleMiddle AgedMicroRNAsgenetic predispositionmiRNAsSNPstype 2 diabetes
Identifiers
PMID41226486
PMCPMC12607382
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