Evidence map›Paper›PMID 41226481›Full record

ArticleInternational journal of molecular sciences2025

Dendritic Polyglycerol Sulfate Reduces Inflammation Through Inhibition of the HMGB1/RAGE Axis in RAW 264.7 Macrophages.

Marten Kagelmacher, Cristina S Quella, Emma Kautz, Anna Klumpp, Felix Weichert, Issan Zhang, Dusica Maysinger, Poornima G Wedamulla, Suzana K Straus, Thomas Risse and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marten KagelmacherInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0002-8956-0340
Cristina S QuellaInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0009-0000-2065-5889
Emma KautzInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Anna KlumppInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Felix WeichertInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0009-0003-5944-2778
Issan ZhangDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0001-8914-4606
Dusica MaysingerDepartment of Pharmacology and Therapeutics, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0002-0017-5201
Poornima G WedamullaDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.ORCID 0000-0001-7649-0411
Suzana K StrausDepartment of Chemistry, University of British Columbia, Vancouver, BC V6T 1Z1, Canada.ORCID 0000-0002-5357-8450
Thomas RisseInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-0228-9189
Rainer HaagInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.ORCID 0000-0003-3840-162X
Marina PigalevaInstitute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
Jens DerneddeInstitute for Laboratory Medicine, Clinical Chemistry, and Pathobiochemistry, Charité University Medicine Berlin, 13353 Berlin, Germany.ORCID 0000-0001-5319-7677

Funding

Deutsche Forschungsgemeinschaft 434130070
6 · The paper itself

Abstract

High Mobility Group Box 1 (HMGB1) is a central pro-inflammatory mediator released from damaged or stressed cells, where it activates receptors such as the Receptor for Advanced Glycation Endproducts (RAGE). Dendritic polyglycerol sulfate (dPGS), a hyperbranched polyanionic polymer, is known for its anti-inflammatory activity. In this study, we examined how dPGS modulates HMGB1-driven signaling in RAW 264.7 macrophages and human microglia. Recombinant human HMGB1 expressed in

Indexed as

Anti-Inflammatory AgentsDendrimersGlycerolHMGB1 ProteinInflammationMacrophagesPolymersReceptor for Advanced Glycation End ProductsAnimalsHumansLipopolysaccharidesMiceNF-kappa BRAW 264.7 CellsSignal TransductionAnti-Inflammatory AgentsDendrimersGlycerolHMGB1 ProteinLipopolysaccharidesNF-kappa BpolyglycerolPolymersReceptor for Advanced Glycation End Productscytokinesdendritic polyglycerol sulfatehigh mobility group box 1inflammationmacrophagesreceptor for advanced glycation end products

Identifiers

PMID41226481
PMCPMC12607995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.