Evidence map›Paper›PMID 41226416›Full record

Observational studyInternational journal of molecular sciences2025

Lymphocyte Phenotypes and Protein-Bound Uremic Toxins as Determinants of Clinical Outcomes in Hemodialysis Patients.

Theodoros Tourountzis, Georgios Lioulios, Stamatia Stai, Steven Van Laecke, Eleni Moysidou, Michalis Christodoulou, Ariadni Fouza, Asimina Fylaktou, Konstantia Kantartzi, Griet Glorieux and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Theodoros TourountzisProtypo Dialysis Center of Thessaloniki, 55535 Thessaloniki, Greece.ORCID 0000-0002-3935-8363
Georgios LiouliosDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.
Stamatia StaiDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.ORCID 0000-0001-6914-9274
Steven Van LaeckeDepartment of Internal Medicine and Pediatrics, Nephrology Unit, Ghent University Hospital, 9000 Gent, Belgium.ORCID 0000-0001-7628-8491
Eleni MoysidouDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.ORCID 0000-0002-6874-7173
Michalis ChristodoulouDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.ORCID 0000-0001-9565-6931
Ariadni FouzaDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.
Asimina FylaktouDepartment of Immunology, National Peripheral Histocompatibility Center, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.
Konstantia KantartziDepartment of Nephrology, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Griet GlorieuxDepartment of Internal Medicine and Pediatrics, Nephrology Unit, Ghent University Hospital, 9000 Gent, Belgium.ORCID 0000-0002-7641-4707
Maria StangouDepartment of Nephrology, School of Medicine, Aristotle University of Thessaloniki, General Hospital "Hippokratio", 54642 Thessaloniki, Greece.ORCID 0000-0003-2496-9863

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of protein bound uremic toxins (PBUTs) and lymphocyte alterations in morbidity and mortality in patients on hemodialysis (HD) is of great concern. The aim of this study was the assessment of association between PBUTs, immunosenescent lymphocytes' phenotype and clinical events [cardiovascular, severe infections (hospitalization due to infection, respiratory infection), all-cause mortality] during 2-year follow-up. In this prospective observational study, lymphocytes' phenotype of 54 patients on HD and 31 age-matched controls was analyzed by flow cytometry, and simultaneously, PBUT serum levels [hippuric acid (HA), indoxyl sulfate (IxS), p-cresyl sulfate (pCS), p-cresyl glycuronide (pCG), in-dole-3-acetic acid (IAA), and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)] were quantified by ultra-performance liquid chromatography. Patients with increased levels of free IxS and total and free HA had higher mortality within a 2-year follow-up period (

Indexed as

LymphocytesRenal DialysisUremic ToxinsAgedCresolsFemaleHippuratesHumansIndicanMaleMiddle AgedPhenotypeProspective StudiesSulfuric Acid EstersCresolsHippurateshippuric acidIndicanSulfuric Acid EstersUremic Toxinshemodialysisimmunosenescencemorbiditymortalityprotein bound uremic toxins

Identifiers

PMID41226416
PMCPMC12607633

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.