Evidence map›Paper›PMID 41226410›Full record

ArticleInternational journal of molecular sciences2025

Potassium-Hydroxide-Based Extraction of Nicotinamide Adenine Dinucleotides from Biological Samples Offers Accurate Assessment of Intracellular Redox Status.

Tamas Faludi, Daniel Krakko, Jessica Nolan, Robert Hanczko, Akshay Patel, Zach Oaks, Evan Ruggiero, Joshua Lewis, Xiaojing Wang, Ting-Ting Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tamas FaludiDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.ORCID 0000-0002-8147-0498
Daniel KrakkoDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Jessica NolanDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Robert HanczkoDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Akshay PatelDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Zach OaksDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Evan RuggieroDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Joshua LewisDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Xiaojing WangDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.
Ting-Ting HuangDepartment of Neurology, Stanford University, Palo Alto, CA 94304, USA.
Ibolya Molnar-PerlInstitute of Chemistry, Department of Analytical Chemistry, L. Eötvös University, H-1117 Budapest, Hungary.
Andras PerlDepartment of Medicine, Norton College of Medicine, State University of New York, Syracuse, NY 13210, USA.ORCID 0000-0002-5017-1348

Funding

NIH HHS AI072648NIH HHS AR076092NIH HHS DK078922
6 · The paper itself

Abstract

The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) is a primary electron donor for both antioxidant enzymes, such as glutathione reductase, and pro-oxidant enzymes, such as NADPH oxidases that produce reactive oxygen species (ROS) and nitric oxide synthases that generate nitric oxide which act as signaling molecules. Monitoring NADPH levels, NADPH/NADP

Indexed as

HydroxidesNADNADPPotassium CompoundsAnimalsCell Line, TumorChromatography, LiquidHepatocytesHumansLiverMass SpectrometryMiceOxidation-ReductionHydroxidesNADNADPPotassium Compoundsalkaline extractionformic acid extractionhepatocellular carcinomahepatocyteliverlupusmethanol extractionNADNADHNADPNADPHtransaldolase

Identifiers

PMID41226410
PMCPMC12607542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.