The Anti-Cancer Potential of Genistein: Single-Cell RNA Sequencing Analysis and Spatial Transcriptome Reveal That Genistein Targets HSD17B1 to Inhibit the Progression of Gastric Adenocarcinoma.

Xianbing Wang, Junyuan Zhang, Jiaying Jiang, Yi Wang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Harnessing Dual Power: Genistein-Loaded Pumpkisomes in Pullulan Microneedles for Potent Antioxidant and Anticancer Therapy Against Ehrlich Ascites Carcinoma and Breast Cancer Cells.Pharmaceutics · 2025
Article

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xianbing WangThe School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0009-0001-9150-8728

Junyuan ZhangThe School of Molecular Sciences, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0009-0007-9262-1072

Jiaying JiangThe State Key Laboratory of Resource Insects, Southwest University, Chongqing 400715, China.

Yi WangBiological Science Research Center, Southwest University, Chongqing 400715, China.ORCID 0000-0002-4706-8171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genistein has anti-cancer effects, but its molecular targets in gastric adenocarcinoma (GA) are unclear. This study used single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) to explore genistein's "drug-gene-cell" interactions in GA. GA- and genistein-related target genes were retrieved and intersected with differentially expressed genes identified from bulk transcriptomic data. Machine learning screened candidates, and survival analysis assessed prognosis. Molecular docking with genistein validated key genes, with molecular dynamics assessing binding stability.

Indexed as

AdenocarcinomaEstradiol DehydrogenasesGenisteinStomach NeoplasmsTranscriptomeDisease ProgressionGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMolecular Docking SimulationPrognosisSequence Analysis, RNASingle-Cell AnalysisEstradiol DehydrogenasesGenisteingastric adenocarcinomagenisteinmolecular dockingsingle-cell RNA sequencing analysisspatial transcriptome

Identifiers

PMID41226409

DOI10.3390/ijms262110369

PMCPMC12609499

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.