Xanthohumol Triggers Pyroptotic in Prostate Cancer Cells via the Caspase-3/GSDME Signaling Pathway.

Jiayin Sun, Shi Li, Zheng Duan, Hao Yu, Junjie Zhang, Jun Xue, Zhongqing Wei

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Synthesis and Cytotoxic Activity Study of Conjugates of N-Acyl Derivatives of 3,5-Bis(benzylidene)-4-piperidones and Phenothiazine.International journal of molecular sciences · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiayin SunThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Shi LiThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Zheng DuanThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Hao YuThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Junjie ZhangThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Jun XueThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Zhongqing WeiThe Second Clinical Medical School of Nanjing Medical University, Nanjing 210011, China.

Funding

National Natural Science Foundation of China 82370781National Natural Science Foundation of China 82470808

6 · The paper itself

Abstract

Xanthohumol (XN), a naturally occurring flavonoid characterized by the presence of prenyl moieties and obtained from hop plants (

Indexed as

Caspase 3FlavonoidsPropiophenonesProstatic NeoplasmsPyroptosisSignal TransductionCell Line, TumorCell ProliferationGasderminsHumansHumulusMaleReactive Oxygen SpeciesCASP3 protein, humanCaspase 3FlavonoidsGasderminsGSDME protein, humanPropiophenonesReactive Oxygen SpeciesxanthohumolGSDMEprostate cancerpyroptoticXanthohumol

Identifiers

PMID41226386

DOI10.3390/ijms262110347

PMCPMC12610606

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.