Evidence map›Paper›PMID 41226297›Full record

ArticleInternational journal of molecular sciences2025

8-Methoxypeucedanin: Evaluation of Anxiolytic Effects and Modulation of Neuronal Activity Related Genes in a Zebrafish Anxiety Mode.

Jarosław Widelski, Monika Maciąg, Natalia Kasica, Barbara Budzyńska, Piotr Podlasz, Simon Vlad Luca, Dafina Fondai, Krystyna Skalicka-Woźniak

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jarosław WidelskiDepartment of Pharmacognosy with Medicinal Plant Unit, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0003-3154-9138
Monika MaciągIndependent Laboratory of Behavioral Studies, Medical University of Lublin, 20-093 Lublin, Poland.
Natalia KasicaDepartment of Animal Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.ORCID 0000-0002-0242-2587
Barbara BudzyńskaIndependent Laboratory of Behavioral Studies, Medical University of Lublin, 20-093 Lublin, Poland.
Piotr PodlaszDepartment of Pathophysiology, Forensic Veterinary Medicine and Administration, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Simon Vlad LucaInstitut de Chimie Organique et Analytique, Université d'Orléans, CNRS, UMR 7311, BP6759, 45067 Orléans, France.
Dafina FondaiDepartment of Pharmacy, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo.
Krystyna Skalicka-WoźniakDepartment of Chemistry of Natural Products, Medical University of Lublin, 20-093 Lublin, Poland.ORCID 0000-0002-9313-5929

Funding

National Sciences Center . 2017/25/N/NZ7/01899
6 · The paper itself

Abstract

For thousands of years, medicinal plants and their constituents have been used, mostly empirically/ethnopharmacologically, to cure patients with central nervous system (CNS) disorders. Anxiolytics derived from natural products (NPs) often share similar mechanisms of action to synthetic ones (e.g., benzodiazepines, BDZs). Although typically as effective as synthetic anxiolytics, NPs are considered to be devoid of the serious side effects linked to the use of BDZs. 8-Methoxypeucedanin (8-MP) is a rare furanocoumarin present in the fruits of

Indexed as

Anti-Anxiety AgentsAnxietyFurocoumarinsNeuronsAnimalsBehavior, AnimalBrain-Derived Neurotrophic FactorDisease Models, AnimalGene Expression RegulationProto-Oncogene Proteins c-fosZebrafishAnti-Anxiety AgentsBrain-Derived Neurotrophic FactorFurocoumarinsProto-Oncogene Proteins c-fosanxietybdnfc-fosDanio reriofuranocoumarinsneural activitythigmotaxis

Identifiers

PMID41226297
PMCPMC12608018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.