Evidence map›Paper›PMID 41226248›Full record

ArticleMolecules (Basel, Switzerland)2025

Unveiling the Role of the Lewis Acids in the Acceleration of Alder-Ene Reactions: A Molecular Electron Density Theory Study.

Luis R Domingo, Patricia Pérez

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Luis R DomingoIndependent Researcher, Avd. Tirso de Molina 20, 46015 Valencia, Spain.ORCID 0000-0002-2023-0108
Patricia PérezFacultad de Ciencias, Departamento de Ciencias Biológicas y Químicas, Universidad San Sebastián, Campus Ciudad Universitaria, Av. del Condor 720, Ciudad Empresarial, Huechuraba, Santiago 8580704, Chile.ORCID 0000-0002-6920-703X

Funding

FONDECYT Chile 1221383
6 · The paper itself

Abstract

The electronic effects of Lewis acids (LAs) in reducing the activation energies of Alder-ene (AE) reactions have been studied within the Molecular Electron Density Theory (MEDT). To this end, the AE reactions of 2-methylbutadiene (2MBD) with formaldehyde (CHO) in the presence of three LAs with increasing acidic character, BH

Indexed as

Alder-ene reactionselectrophilicityglobal electron density transferLewis acid catalystsmolecular electron density theoryrelative interacting atomic energies

Identifiers

PMID41226248
PMCPMC12609831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.