Evidence map›Paper›PMID 41226234›Full record

ArticleMolecules (Basel, Switzerland)2025

The Application of Poly(2-(hydroxymethyl)acrylic Acid as a Functional Nanomaterial to Ensure the Biosafety of Herbal Decoctions.

Yifei Guo, Xueqing Sun, Xiangsheng Zhao, Xiangtao Wang, Meihua Han, Zhengqi Dong

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yifei GuoHainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou 570311, China.
Xueqing SunState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
Xiangsheng ZhaoHainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou 570311, China.
Xiangtao WangState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
Meihua HanState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.
Zhengqi DongState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China.

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-031CAMS Innovation Fund for Medical Sciences 2021-I2M-1-071Hainan Province Science and Technology Special Fund ZDYF2023SHFZ140Wanning Science and Technology Special Fund 2023wnkj09
6 · The paper itself

Abstract

Heavy metal ions in herbal medicine sometimes exceed the standard limit, inducing severe and harmful problems in human health. Exploring new nanomaterials to chelate heavy metal ions and reduce their concentration in herbal decoctions could be a solution route. In this study, the nanoadsorbent poly(2-(hydroxymethyl)acrylic acid (PHMAA) was prepared via free radical polymerization and the hydrolysis method. PHMAA showed excellent dispersion in aqueous solution and self-assembled into spherical aggregates with a negative surface charge. After freeze-drying, PHMAA was a white solid powder with a loose porous structure. PHMAA presented no significant influence on the cell viability and weight of normal BALB/c mice. PHMAA showed good removal efficiency towards Cd

Indexed as

Drugs, Chinese HerbalNanostructuresPolymethacrylic AcidsAnimalsCadmiumCell SurvivalHumansMiceMice, Inbred BALB CCadmiumDrugs, Chinese HerbalPolymethacrylic AcidsbiosafetyCd2+ ionsherbal decoctionsnanoadsorbentsremoval rate

Identifiers

PMID41226234
PMCPMC12608372

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.