Assembly of Diverse 3-Methylenetetrahydrofurans via Palladium-Catalyzed Cascade Carboetherification of Buta-1,3-Dienes with Alkynols.

Yin-Long Lai, Yanan Niu, Kaitong Zeng, Huanfeng Jiang, Huishi Guo, Sheng-Ling Zhang, Jianxiao Li

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Facile Assembly of Structurally Diverse 2Molecules (Basel, Switzerland) · 2026
Article

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Authors and funding

7 authors.

Yin-Long LaiCollege of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, China.

Yanan NiuKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Kaitong ZengKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Huanfeng JiangKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.ORCID 0000-0002-4355-0294

Huishi GuoCollege of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, China.

Sheng-Ling ZhangCollege of Chemistry and Civil Engineering, Shaoguan University, Shaoguan 512005, China.

Jianxiao LiKey Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.ORCID 0000-0002-5246-5729

Funding

Education Department of Guangdong Province 2023KTSCX135, 2023ZDZX2059National Key Research and Development Program of China 2022YFB4101800National Training Program of Innovation and Entrepreneurship for undergraduates 202510561040

6 · The paper itself

Abstract

Tetrahydrofuran scaffolds have found promising applications in both pharmaceutical chemistry and organic synthesis but remain underexplored owing to the challenges associated with their preparation. Herein, we have developed a robust synthetic strategy for the palladium-catalyzed cascade annulation reaction of buta-1,3-dienes with alkynols for the assembly of diverse 3-methylenetetrahydrofurans with excellent functional group compatibility and good regioselectivity. More importantly, this protocol features broad substrate scope, good functional group tolerance, and good step- and atom-economy. A diverse array of functional groups such as halogen atoms, aldehyde, nitro, ester, and several aromatic heterocycles were also nicely tolerated and provided the corresponding products in moderate to good yields. It is noteworthy that the practicability is further verified by gram-scale experiments and synthetic transformation to access organic functional molecules.

Indexed as

alkynescarboetherificationcascade cyclizationpalladium catalysistetrahydrofuran heterocyclics

Identifiers

PMID41226204

DOI10.3390/molecules30214244

PMCPMC12608958

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