ArticleMolecules (Basel, Switzerland)2025
Triaxial Electrospun Nanofiber Membranes for Prolonged Curcumin Release in Dental Applications: Drug Release and Biological Properties.
Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Electrospun Integrated Janus Nanofibers for Asynchronous Delivery of Finasteride and Tibetan Medicine.Pharmaceutics · 2026Article
- Self-Biased Electrospun Triaxial Ferrite-PZT Nanofibers and Studies on Magneto-Electric Coupling.Nanomaterials (Basel, Switzerland) · 2026Article
- Janus Films Fabricated Using Modified Electrospinning for Converting the Dosage Form of Watermelon Frost.ACS omega · 2026Article
- Scalable and Systematical Conversions of Domestic Wastes to Core-Sheath Nanofibers for Photocatalytic Degradation of Antibiotics.ACS omega · 2026Article
- Fast Dissolving Resveratrol-Polyvinylpyrrolidone Nanofibrous Films Fabricated in Bulk Using a Special Hole Electrospinning Technique.Polymers · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triaxial electrospinning was used to fabricate fiber membranes composed of polycaprolactone (PCL), poly(lactic-co-glycolide) (PLGA), and gelatin (GT), designed as carriers for curcumin (Cur) delivery. Here, synthetic polyesters acted as core and shell layers, while GT formed the middle layer containing Cur at varying concentrations. This paper aimed to demonstrate the effect of a shell layer by rearranging the core and shell layers on the kinetics of model drug delivery. In vitro release results indicated the shell layer considerably affected the release behavior, reducing the initial burst release by up to 28% in triaxial fibers compared to coaxial fibers in PLGA-shell forms. The release kinetics were interpreted using the Gallagher-Corrigan model. The membranes were also evaluated for their morphological properties. PLGA-shell-layered triaxial fibers exhibited pore sizes up to approximately 11 µm, small enough to prevent cell migration, while providing higher permeability. The surface wettability analysis of the developed fibers showed that all forms exhibited hydrophilic properties. Furthermore, the cytocompatibility of the fiber membranes was confirmed with the relative cell viability of over 80%. Triaxial fibers with different shell layers displayed similar release trends, yet fibers with the PLGA shell layer demonstrated more favorable performance, attributed to its layer configuration. These findings suggest that the strategic positioning of polymers in triaxial electrospun membranes could be pivotal in optimizing drug delivery systems.
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