Haloamines of the Neurotransmitter γ-Aminobutyric Acid (GABA) and Its Ethyl Ester: Mild Oxidants for Reactions in Hydrophobic Microenvironments and Bactericidal Activity.

Luiza de Carvalho Bertozo, Markus Nagl, Valdecir Farias Ximenes

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Luiza de Carvalho BertozoSão Paulo State University (UNESP), School of Sciences, Bauru 17033-360, Brazil.ORCID 0000-0002-5025-7707

Markus NaglInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-1225-9349

Valdecir Farias XimenesSão Paulo State University (UNESP), School of Sciences, Bauru 17033-360, Brazil.ORCID 0000-0003-2636-3080

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001National Council for Scientific and Technological Development 302121/2022-6State of Sao Paulo Research Foundation 2024/00959-0

6 · The paper itself

Abstract

N-chlorotaurine (Tau-Cl) is a mild oxidizing haloamine formed from the reaction of hypochlorous acid (HOCl) with taurine (2-amino-ethanesulfonic acid). It is widely used as a topical antiseptic. In this study, we investigated haloamines derived from the neurotransmitter γ-aminobutyric acid, specifically GABA chloramine and bromamine (GABA-Cl, GABA-Br), as well as their halogenated γ-aminobutyric acid ethyl esters (GABAet-Cl, GABAet-Br). Due to their higher hydrophobicity, the esterified haloamines were more potent oxidants in the presence of lyophilic surfactant micelles, demonstrating their greater ability to access hydrophobic environments. By using fluorescent azapentalenes as molecular targets incorporated into sodium dodecyl sulfate (SDS) micelles, the second-order oxidation rate constants (k

Indexed as

AminesAnti-Bacterial Agentsgamma-Aminobutyric AcidNeurotransmitter AgentsOxidantsEscherichia coliEstersHydrophobic and Hydrophilic InteractionsMicellesMicrobial Sensitivity TestsOxidation-ReductionSodium Dodecyl SulfateStaphylococcus aureusTaurineAminesAnti-Bacterial AgentsEstersgamma-Aminobutyric AcidMicellesNeurotransmitter AgentsN-halamineOxidantsSodium Dodecyl SulfateTaurineantisepticbactericidal activitybromamineschloraminesGABAmicellestaurine

Identifiers

PMID41226188

DOI10.3390/molecules30214227

PMCPMC12610792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.