ArticleBMC psychology2025
Trauma and psychological impact in fibromyalgia and other central sensitization syndromes: the role of anxiety and pain acceptance.
Article in BMC psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Beyond Structural Pathology: Central Sensitization and Chronic Pain with Reference to Lumbar Disc Herniation-A Narrative Review.Brain sciences · 2026Review
- Impact of Post-Traumatic Stress Disorder Management Through Reconsolidation Therapy on Fibromyalgia Syndrome: A Pilot Study.Biomedicines · 2026Article
- Acupoint Sensitivity in Patients with Primary Insomnia and Its Correlation with Polysomnography and Heart Rate Variability: A Cross-Sectional Study.Nature and science of sleep · 2026Article
- Perioperative Dynamic Changes and Independent Associations of Pressure Pain Threshold in Trauma Patients: A Prospective Longitudinal Study.Pain research & management · 2026Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Recent literature suggests an association between traumatic experiences and central sensitization syndromes (CSS), particularly fibromyalgia (FM). However, few studies have explored the specific variables involved in the relationship between post-traumatic stress disorder (PTSD) and the severity of central sensitization. This study aimed to compare the frequency and characteristics of trauma, PTSD, and clinical symptoms among FM patients, other CSS patients, and healthy controls, and to identify potential mediators between intensity of post-traumatic stress symptoms and central sensitization severity.A cross-sectional study was conducted with 82 women with FM, 41 women with other CSS, and 43 healthy controls. The assessment protocol included a semi-structured interview, self-report measures of PTSD, central sensitization, pain and pain attitudes, sleep quality, fatigue, anxiety, depression, and disability; and objective measures to assess pressure pain thresholds via a digital algometry and sleep quality via actigraphy. Participants wore the actigraphs for one week. Statistical analyses included descriptive statistics, group comparisons using chi-square tests and one-way ANOVA with post-hoc tests, effect size estimations, correlation analyses, and a multiple mediation model.FM patients reported higher trauma frequency and severity, and a higher prevalence of PTSD and intensity of post-traumatic stress symptoms than the CSS and healthy participants. The FM group also exhibited greater impairment across all clinical variables assessed, followed by the CSS group and healthy individuals. Within FM patients, those with PTSD showed more severe clinical profile than those without PTSD, highlighting the correlations between the intensity of post-traumatic stress symptoms and several clinical symptoms. In this subgroup of FM and PTSD, anxiety and pain acceptance are significant mediators in the relationship between post-traumatic stress symptoms and central sensitization.The findings highlight the importance of assessing and addressing PTSD in patients with CSS, particularly FM. Individuals with FM/CSS may require a tailored treatment approach that emphasizes addressing emotions such as anxiety and increasing acceptance. Trauma resolution may have a relevant impact on FM/CSS and contribute substantially to improving the quality of life in this complex patient population.
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