ArticleMolecular brain2025
Septin5 deficiency impairs both recent and remote contextual fear memory.
Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Impairment of novelty-dependent hippocampal behavioural tagging in Septin5-deficient mice.Molecular brain · 2026Article
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Authors and funding
14 authors.
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Abstract
Septin-3 and Septin-5 are components of the septin cytoskeleton highly expressed in the nervous system, yet the extent of their shared and distinct roles is not fully understood. We recently demonstrated that Septin-3 regulates late-phase long-term potentiation (L-LTP)-dependent invasion of smooth endoplasmic reticulum (sER) into dentate gyrus (DG) spines. Septin3−/− mice exhibit normal synaptic ultrastructure in the hippocampal DG, CA3, and CA1, yet the fraction of sER-containing spines is reduced; behaviorally, they show selective deficits in 1-day object recognition and 1-day contextual fear memory, whereas cued fear conditioning and contextual memory tested at 1 month are intact. Here, using adult male Septin5−/− mice, we tested whether morphological and behavioral phenotypes identified in Septin3−/− mice are shared or subunit-specific. Electron microscopy showed no detectable differences in synapse density, spine volume, and postsynaptic density (PSD) area in the hippocampal DG, CA3, and CA1, with an unchanged fraction of sER-containing spines relative to wild-type littermates. Behaviorally, Septin5−/− mice were impaired in recent (1 day) and remote (1 month) contextual fear memory, but were normal in 1-day novel object recognition memory and in recent and remote cued fear memory. The shared and distinct structural and behavioral phenotypes observed in Septin5−/− and Septin3−/− mice suggest either sER-independent common mechanisms or subunit-specific ones for recent contextual fear memory deficit, and indicate a Septin-5-dependent contribution to remote contextual fear memory.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.