SynthesisEuropean journal of medical research2025
Influence of early enteral nutrition on mortality of adult patients with sepsis: a meta-analysis of randomized controlled trials.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Association between prognostic nutritional index and mortality in patients with sepsis-associated delirium: a retrospective cohort study using the MIMIC-IV database.BMC nutrition · 2026Article
- Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits.EMBO molecular medicine · 2026Review
- Achieving ≥70% of energy requirements during early enteral nutrition and short-term inflammatory-metabolic profiles in critically ill patients with sepsis: a prospective cohort study.Frontiers in nutrition · 2026Article
- Nutritional Risk and 30-Day In-Hospital Mortality in Adults With Sepsis and Septic Shock: A Retrospective Cohort Study.Journal of nursing management · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEarly enteral nutrition (EEN) has been proposed to improve clinical outcomes in critically ill patients with sepsis. However, the survival benefit of EEN remains uncertain. This meta-analysis aimed to evaluate the effect of EEN on all-cause mortality in adult patients with sepsis.
methodsA systematic search of PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang was conducted up to May 25, 2025. Randomized controlled trials (RCTs) comparing EEN (initiated within 24-48 h of admission or sepsis diagnosis) vs. non-early enteral nutrition (delayed enteral nutrition or parenteral nutrition) in adult septic patients were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model by incorporating the influence of potential heterogeneity.
resultsTen RCTs involving 582 patients (281 EEN, 301 controls) were included. Compared to controls, EEN significantly reduced all-cause mortality (OR: 0.59; 95% CI 0.37-0.94; p = 0.03), with no significant statistical heterogeneity (I
conclusionsEEN significantly reduces mortality in adult patients with sepsis. High-quality RCTs are warranted to determine the optimal regimen of EEN in this population.
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