Evidence map›Paper›PMID 41225577›Full record

ArticleDiagnostic pathology2025

Molecular abnormalities and clinical features in adult patients with acute myeloid leukemia in Thailand.

Pichika Chantrathammachart, Artit Jinawath, Teeraya Puavilai, Lalida Arsa, Pornnapa Police, Phichchapha Noikongdee, Tichayapa Phojanasenee, Pakatorn Sae-Lim, Thanakrit Piyajaroenkij, Phatsorn Choksomnuk and 2 more

Abstract read
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In one paragraph

Article in Diagnostic pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Pichika ChantrathammachartDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Artit JinawathPathology Department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Teeraya PuavilaiDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Lalida ArsaPathology Department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pornnapa PoliceDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Phichchapha NoikongdeeDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Tichayapa PhojanaseneeDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pakatorn Sae-LimPathology Department, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Thanakrit PiyajaroenkijDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Phatsorn ChoksomnukDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Suporn ChuncharuneeDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pimjai NiparuckDivision of Hematology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. niparuckblue@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genetic heterogeneity observed in acute myeloid leukemia (AML) contributes to a wide range of clinical presentations and prognoses. We conducted a retrospective study to investigate genetic abnormalities, clinical characteristics, and survival of AML patients.

methodsTargeted exome analysis of 25 genes using a QIAact Myeloid DNA UMI Panel with the GeneReader NGS was performed.

resultsDe novo AML (dAML) and secondary AML (sAML) were observed in 163 and 56 patients, respectively. ASXL1, SRSF2, and RUNX1 mutations were significantly observed in sAML patients. Among dAML patients, mutant IDH1, ASXL1, TP53, and TET2 were associated with low WBC count (< 4 × 10

conclusionsThe complexity of AML was influenced by various cytogenetic and molecular abnormalities, which contributed to patients' heterogeneous presentation and survival outcomes. In addition to the previous data, IDH1, IDH2, and DNMT3A mutations might have affected survival outcomes in AML patients in our retrospective cohort. However, further studies with larger sample sizes are needed to validate these observations.

Indexed as

Leukemia, Myeloid, AcuteAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedMutationNucleophosminRetrospective StudiesThailandYoung AdultNPM1 protein, humanNucleophosminAcute myeloid leukemiaClinical featuresCytogenesisMolecular abnormality

Identifiers

PMID41225577
PMCPMC12613783

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.