SynthesisSystematic reviews2025
Platelet parameters as potential biomarkers for sepsis: a systematic review and meta-analysis.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Article
- Association of MTHFR and platelet-related blood cell ratio parameters with ischemic stroke in Gansu population.BMC cardiovascular disorders · 2026Article
- Thromboelastography-Based Risk-Stratified Transfusion Strategy in Acute Stanford Type A Aortic Dissection: A Predictive Model and Prospective Validation.Journal of clinical medicine · 2026Article
- Association between platelet count and 30-day mortality in community-acquired pneumonia patients receiving systemic glucocorticoids therapy.Scientific reports · 2026Article
- Diagnostic Value of Mean Platelet Volume and Hematological Inflammatory Ratios in Brucellosis: A Case-Control Study.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundSepsis remains a major global health issue, especially in low- and middle-income countries (LMICs) with limited diagnostic resources. This meta-analysis evaluates platelet index ratios (mean platelet volume-to-platelet count, MPV/PLT; platelet distribution width-to-platelet count, PDW/PLT; and platelet distribution width-to-plateletcrit, PDW/PCT) as cost-effective biomarkers for sepsis diagnosis and prognosis in resource-constrained settings.
methodsA systematic search was conducted for studies evaluating platelet parameter ratios in sepsis. Inclusion criteria comprised the following: (1) cohort/case-control designs; (2) non-duplicated datasets; (3) available quantitative data for meta-analysis. Exclusion criteria included reviews, abstracts, letters to the editor, and studies with incomplete data. Synthesis methods employed random-effects models to calculate standardized mean differences (SMD) and diagnostic metrics (sensitivity, specificity, etc.), with heterogeneity assessed via I-squared statistics. Publication bias was evaluated through funnel plots and Egger's test.
resultsFourteen studies were included. The results revealed that MPV/PLT ratios were significantly higher in neonatal (SMD = 1.48, P = 0.004) and adult sepsis patients (SMD = 0.35, P < 0.001) than in controls. Survivors had significantly lower MPV/PLT ratios than non-survivors in both children/neonate (SMD = 0.67, P < 0.01) and adult group (SMD = 0.41, P < 0.01), with similar trends observed in longitudinal assessments. PDW/PLT was also lower in pediatric survivors (P = 0.009), while no significant differences were found for MPV/PCT in neonates or PDW/PLT in adults. For diagnosing sepsis, MPV/PLT had a sensitivity of 0.55 and specificity of 0.71 in adults, and 0.58 and 0.87 in neonates. For predicting mortality, neonatal sepsis showed higher sensitivity (89%) and specificity (73%) than adult sepsis (63%, 58%). In LMICs, MPV/PLT was elevated at admission in both age groups but was linked to survival only in neonates.
conclusionThe MPV/PLT ratio shows promise as a cost-effective biomarker for sepsis diagnosis and prognosis, particularly in neonatal patients, with important potential applications in LMICs. SYSTEMATIC REVIEW REGISTRATION: This study has been registered on the international platform of registered systematic review and meta-analysis protocols (INPLASY) (Registration Number: INPLASY202540096). https://doi.org/10.37766/inplasy2025.4.0096 .
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