Evidence map›Paper›PMID 41225438›Full record

ArticleBMC gastroenterology2025

Anticoagulation therapy for intra-abdominal hypertension in patients with acute pancreatitis.

Yan Ge, Li Ma, Wenwu Sun, Bing Zhao, Ying Chen, Zhitao Yang, Erzhen Chen, Weisong Jiang, Enqiang Mao, Tongtian Ni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan Ge *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Li Ma *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Wenwu Sun *Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Bing ZhaoDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Ying ChenDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Zhitao YangDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Erzhen ChenDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China.
Weisong JiangDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China. iamjiangweisong@163.com.
Enqiang MaoDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China. maoeq@yeah.net.
Tongtian NiDepartment of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No. 197, Ruijin er Road, Huangpu District, Shanghai, 200025, China. topntt@126.com.

Funding

Clinical Technology Innovation Project of Shanghai Hospital Development Center of China SHDC22021304Health Commission and Department of Science and Technology of Tibet Autonomous Region XZ2024ZR-ZY052(Z)Science and Technology Commission of Shanghai Municipality 23015830500
6 · The paper itself

Abstract

backgroundIntra-abdominal hypertension (IAH) is a common complication in patients with acute pancreatitis (AP) and can lead to multiple organ failure. The efficacy of anticoagulant therapy for IAH in patients with acute pancreatitis is unclear. The objective of this study aimed to investigate the effects of anticoagulant therapy on IAH in patients with acute pancreatitis. MATERIALS AND

methodsA total of 49 AP patients with IAH were included in this retrospective study, with 34 patients in the anticoagulant group and 15 patients in the non-anticoagulant group. The effects of anticoagulant therapy on intra-abdominal pressure, inflammation markers, disease severity, and imaging indices were compared between the two groups.

resultsThe anticoagulant group had significantly lower intra-abdominal pressure at 60 h of therapy compared to the non-anticoagulant group. In addition, inflammation markers and modified Marshall score were significantly improved in the anticoagulant group after 7 days of therapy. There was no significant difference in imaging indices, length of stay and mortality in hospital between the two groups. No adverse bleeding events or allergic reactions occurred during the treatment period. No significant difference was found in the rate of splanchnic vein thrombosis and portal hypertension between the two groups six months after the onset of the disease.

conclusionAnticoagulant therapy may be a potential treatment option for IAH in patients with acute pancreatitis.

Indexed as

AnticoagulantsIntra-Abdominal HypertensionPancreatitisAcute DiseaseAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexAnticoagulantsAcute pancreatitisAnticoagulant therapyIntra-abdominal hypertensionPrognosis

Identifiers

PMID41225438
PMCPMC12613669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.