Evidence map›Paper›PMID 41225428›Full record

SynthesisBMC gastroenterology2025

Gamma-glutamyltransferase and the survival of hepatocellular carcinoma patients after transarterial chemoembolization: a meta‑analysis and systematic review.

Zixin Huang, Manli Zhou, Sisi Feng, Xiaomin Xiao, Baiyun Zhong

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zixin HuangDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China.
Manli ZhouDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China.
Sisi FengDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China.
Xiaomin XiaoDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China.
Baiyun ZhongDepartment of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan, 410083, China. zby@csu.edu.cn.

Funding

Key Research and Development Program of Hunan Province of China 2024JK2107Natural Science Foundation of Hunan Province 2022JJ30987
6 · The paper itself

Abstract

objectivePlentiful studies have reported that preoperative gamma-glutamyltransferase (GGT) had a strong relationship with the prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE). Nevertheless, due to the small sample size and contradictory conclusions, the predictive function remains indefinite. To investigate the relationship between pretreatment GGT value and clinical outcomes in HCC patients undergoing TACE, a meta-analysis including 10 articles was constructed.

methodStudies were searched in PubMed, Embase, Web of Science, Cochrane Library, CNKI, and Wanfang database. Pooled Hazard Ratio (HR) or Odd Ratio (OR) with its 95% confidence intervals was calculated to evaluate the prognostic value of pretreatment GGT in HCC patients undergoing TACE.

resultTen studies with 3274 patients were included in our meta-analysis. The pooled results show that elevated pretreatment GGT has a close relationship to poorer OS (HR 1.72; 95%CI: 1.48-2.01, P < 0.00001, I

conclusionThe result of our meta-analysis indicates that pretreatment GGT had a significant relationship with the clinical outcome in HCC patients after TACE and can serve as an useful marker for predicting overall survival.

trial registrationProspero number: CRD42024504715.

Indexed as

Carcinoma, HepatocellularChemoembolization, Therapeuticgamma-GlutamyltransferaseLiver NeoplasmsBiomarkers, TumorFemaleHumansMalePrognosisBiomarkers, Tumorgamma-GlutamyltransferaseGamma-glutamyltransferaseHepatocellular carcinomaMeta-analysisPrognostic biomarkerTransarterial chemoembolization

Identifiers

PMID41225428
PMCPMC12613662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.