SynthesisBMC pregnancy and childbirth2025
The efficacy of adjuvant therapies in improving endometrial function of women undergoing assisted reproductive technology: a systematic review and network meta-analysis.
Synthesis in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Value of Platelet-Rich Plasma Treatment in Reproductive Disorders: An Umbrella Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Pooled it
- Special Issue "Current Trends and Future Challenges in Assisted Reproduction".Journal of personalized medicine · 2026Article
- Endometrial dysfunction in embryo implantation: from molecular mechanisms to clinical management.Frontiers in reproductive health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveAssessment of the endometrium is an essential component in assisted reproduction. While various adjuvant therapies have been used to improve endometrial function, these results are controversial.
methodsThis meta-analysis aimed to compare the effectiveness of various adjuvant treatment strategies in improving the endometrial thickness and clinical outcome of women undergoing assisted reproduction technology (ART). The PubMed, Embase, and Cochrane Library databases were systematically searched for articles published from database inception to 30 December 2022, without language restrictions.
resultsSixteen RCTs involving 1325 patients and 4 prospective trials involving 379 patients were ultimately included in our study. Compared with controls, Sildenafil (WMD: 1.66, CI 0.59-2.74), PRP (1.34, 0.54-2.15), and G-CSF (1.27, 0.62-1.93) were significantly improved endometrial thickness. With regard to the Biochemical pregnancy rate, only PRP (4.28, 1.26-14.56) were associated with a significantly increased of BPR, compared with controls. With regard to clinical pregnancy rate, Aspirin, G-CSF, GH and PRP showed a better CPR than control (1.87, 1.06-3.29; 2.03, 1.23-3.34; 1.73, 1.02-2.94; 2.66, 1.27-5.57, respectively). None of the included adjuvant treatments were significantly different from control or from each other on miscarriage rate, implantation rate and live birth rate. The findings from subgroup analysis we planned study population did not differ significantly from those of the primary analyses for most comparisons.
conclusionsFor women undergoing assisted reproductive technology, using adjuvant treatment with Sildenafil, PRP and G-CSF showed better endometrial thickness and clinical outcomes, and in women with thin endometrium, the results were similar to the primary analyses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.