Observational studyBMC emergency medicine2025
Can leukocyte count predict the presence of post-traumatic lesions on the WBCT in clinically stable severe trauma patients? A retrospective study.
Observational study in BMC emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere grade C trauma patients usually benefit from whole-body computed tomography (WBCT) to search for traumatic lesions, in the absence of clinical signs. The systematic use of WBCT in clinically stable patients with severe trauma remains controversial.
objectiveThe aim of this study was to evaluate the diagnostic value of the blood leukocyte count in predicting the existence of traumatic lesions on WBCT in grade C severe trauma patients.
methodsThis was an observational, retrospective, monocentric study of severe grade C trauma patients who underwent WBCT and leukocyte blood testing in the emergency department. The diagnosis of post-traumatic injury on WBCT was based on the detection of cranial, thoracic, abdominal, large-vessel, spinal and pelvic injuries. The primary endpoint was blood leukocyte count.
resultsEight hundred and six patients were included, 301 (37.3%) had severe traumatic lesions and 505 (62.7%) did not. The leukocyte count was significantly higher in patients with traumatic lesions than in those without (15.8 G/L ± 5.1 vs. 11.0 G/L ± 4.1; p < 0.01). The AUC of the ROC curve derived from this sample was 0.79 [0.75; 0.82], corresponding to a good diagnostic value. Using the optimal threshold of 13.5 G/L, sensitivity was 66% [60%; 71%], specificity 80% [77%; 84%], PPV 67% [61%; 72%] and NPV 80% [76%; 83%].
conclusionThe leukocyte count on venous blood assay was significantly higher in severe grade C trauma patients with severe traumatic lesions on the WBCT but doesn’t seem to be a sufficient criterion to avoid WBCT. Its analysis coupled with other biological or clinical criteria could be studied.
trial registrationThis study was approved by the local institutional review board (no. 24.02.01).
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