Evidence map›Paper›PMID 41225359›Full record

ArticleBMC microbiology2025

Longitudinal dysbiosis of gut bacteriome and mycobiome in patients with severe acute pancreatitis and its association with mortality.

Cong He, Jinyun Wang, Ling Ding, Xueyang Li, Yi Hu, Wenhua He, Liang Xia, Huifang Xiong, Xin Huang, Yupeng Lei and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cong He *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Jinyun Wang *Department of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Ling DingDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Xueyang LiDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Yi HuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Wenhua HeDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Liang XiaDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Huifang XiongDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Xin HuangDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Yupeng LeiDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Lingyu LuoDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Nonghua LuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China.
Yin ZhuDepartment of Gastroenterology, Jiangxi Provincial Key Laboratory of Digestive Diseases, Jiangxi Clinical Research Center for Gastroenterology, Digestive Disease Hospital, The First Affiliated HospitalJiangxi Medical CollegeNanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang, Jiangxi Province, 330006, China. ndyfy01977@ncu.edu.cn.

Funding

Jiangxi Province's Thousand Talents Plan for introducing and cultivating high-level talents in innovation and entrepreneurship jxsp2019201028National Natural Science Foundation of China 82370661National Natural Science Foundation of China 82400761Science and Technology Innovation Team cultivation project of the First Affiliated Hospital of Nanchang University YFYKCTDPY202202
6 · The paper itself

Abstract

backgroundThe dysbiosis of gut microbiome is known to have a significant impact on the progression of sever acute pancreatitis (SAP). This study intends to investigate the alteration of gut microbiome in SAP patients during hospitalization and its association with mortality. Bacterial and fungal compositions of the fecal microbiota were determined via 16S and ITS1 sequencing, respectively.

resultsOur findings indicated that SAP patients exhibited bacterial and fungal dysbiosis either at the time of admission or within the first 72 h of admission prior to any antibiotic treatment, characterized by reduced biodiversity, lower abundances of Blautia, Bifidobacterium, and increased Escherichia-Shigella, Enterococcus, and Candida. The overall microbiome was partially restored post-treatment in survivors, including commensal Bifidobacterium enhancement. In contrast, non-survivors experienced sustained perturbations during hospitalization, with over-representation of pathogenic Enterococcus and Candida. A classifier based on 20 optimal bacteria markers showed superior efficiency for predicting mortality. Interestingly, the abundances of Acinetobacter, Klebsiella and Candida were considerably elevated in the gut of patients who subsequently developed infectious complications.

conclusionsOur study provided a comprehensive profile of gut bacteriome and mycobiome in SAP patients and identified the temporal trajectory alterations of microbiome associated with mortality. These findings underscore the importance of early recognition of pathobiome states and the potential role for the modulation of microbiota during the development of SAP.

Indexed as

BacteriaDysbiosisFungiGastrointestinal MicrobiomeMycobiomePancreatitisAdultAgedFecesFemaleHumansLongitudinal StudiesMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SGut microbiomeInfectionMycobiomePathobiotaSevere acute pancreatitisShort chain fatty acids

Identifiers

PMID41225359
PMCPMC12613924

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.