Evidence map›Paper›PMID 41225336›Full record

ArticleBMC microbiology2025

Gastric cancer-associated bacteria exhibit distinct butyrate and pyruvate metabolism: a metabolomic analysis of F. nucleatum, N. subflava, and H. pylori.

Ryota Niikura, Yoku Hayakawa, Takahiro Mukai, Yoichi Kato, Naofumi Yoshida, Mitsuhiro Fujishiro

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryota NiikuraGastroenterological Endoscopy, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan.
Yoku HayakawaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan. yhayakawa-tky@umin.ac.jp.
Takahiro MukaiNIPRO CORPORATION, Senriokashinmachi, Settsu-city, Osaka, Japan.
Yoichi KatoNIPRO CORPORATION, Senriokashinmachi, Settsu-city, Osaka, Japan.
Naofumi YoshidaNIPRO CORPORATION, Senriokashinmachi, Settsu-city, Osaka, Japan.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundButyrate and pyruvate are central metabolites in anaerobic microbial metabolism, with key roles in gastrointestinal physiology. We recently identified Fusobacterium nucleatum (F. nucleatum) and Neisseria subflava (N. subflava) as non-Helicobacter pylori (H. pylori) bacteria potentially involved in gastric cancer development. However, the metabolic pathways distinguishing F. nucleatum, N. subflava, and H. pylori remain poorly characterized.

methodsWe performed capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS) to profile the metabolic outputs of these three species under isolated culture conditions.

resultsDistinct metabolic signatures were observed: F. nucleatum predominantly synthesized butyrate via the acetyl-CoA pathway, whereas N. subflava produced high levels of pyruvate and employed a cyclical route regenerating pyruvate from acetyl-CoA. In contrast, H. pylori lacked significant production of either metabolite.

conclusionsThis study delineates species-specific metabolic programs among gastric cancer-associated bacteria and highlights unique butyrate and pyruvate metabolism as a potential axis of microbe-host and microbe-microbe interaction in the gastric environment.

Indexed as

ButyratesFusobacterium nucleatumHelicobacter pyloriPyruvic AcidStomach NeoplasmsAcetyl Coenzyme AHumansMetabolic Networks and PathwaysMetabolomicsAcetyl Coenzyme AButyratesPyruvic AcidCE-TOFMSFusobacteriumGastric microbiotaGastrointestinal cancerMetabolitesNeisseria

Identifiers

PMID41225336
PMCPMC12613646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.