Evidence map›Paper›PMID 41225269›Full record

ArticleHuman cell2025

ONECUT2-driven activation of ADAMTS14 boosts colorectal cancer stemness via Wnt pathway.

Yicheng Jiang, Xingping Tan

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yicheng JiangDepartment of Oncology, People's Hospital of Chongqing Hechuan, No. 1366, Xi'er'an Avenue, Nanban Subdistrict, Hechuan District, Chongqing, 401520, China.
Xingping TanDepartment of Oncology, People's Hospital of Chongqing Hechuan, No. 1366, Xi'er'an Avenue, Nanban Subdistrict, Hechuan District, Chongqing, 401520, China. xingping_tan@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The malignant progression of colorectal cancer (CRC) is closely related to cell stemness, but its regulatory mechanism has not been fully elucidated. This study found that ADAMTS14 was significantly highly expressed in CRC tissues and cell lines and was associated with poor prognosis in patients. Functional experiments have confirmed that ADAMTS14 enhances the stemness characteristics (such as upregulation of ALDH1A1, ALDH1A3, and CD133 expression) and spheroidization ability of CRC cells by activating the Wnt signaling pathway. Further mechanism studies have shown that the transcription factor ONECUT2 is also highly expressed in CRC and indicates a poor prognosis, and it can directly activate its transcription by binding to the ADAMTS14 promoter region. In conclusion, this study has revealed a novel mechanism by which the ONECUT2/ADAMTS14/Wnt axis regulates the stemness of CRC cells, providing a potential molecular target for targeted intervention.

Indexed as

ADAMTS ProteinsColorectal NeoplasmsHomeodomain ProteinsTranscription FactorsWnt Signaling PathwayCell LineGene Expression Regulation, NeoplasticHumansNeoplastic Stem CellsPrognosisTranscription, GeneticADAMTS14 protein, humanADAMTS ProteinsHomeodomain ProteinsONECUT2 protein, humanTranscription FactorsADAMTS14Cell stemnessColorectal cancerONECUT2Wnt signaling pathway

Identifiers

PMID41225269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.