ArticleScientific reports2025
Identification of novel triazolopyrimidines as potent α-glucosidase inhibitor through design, synthesis, biological evaluations, and computational analysis.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Potent and selective α-glucosidase inhibition by coumarin-triazole conjugates: design,RSC advances · 2026Article
- New coumarin-chalcone-triazole hybrids as promising anti-diabetic agents: from molecular design toRSC advances · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
α-Glucosidase inhibitors are widely used in the management of type 2 diabetes mellitus (T2DM) by delaying carbohydrate digestion and reducing postprandial blood glucose levels. However, current drugs suffer from limited efficacy and gastrointestinal side effects, highlighting the need for novel inhibitors with improved potency and selectivity. In this study, a novel series of 5,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidin-6-amines 9a-9t was designed and prepared through an efficient, straightforward synthetic route. Subsequently, they were evaluated for their α-glucosidase inhibitory activity, with compound 9s exhibiting the most potent inhibition (IC
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Registered trials
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