ReviewAdvances in experimental medicine and biology2026
Immune Responses in Orthodontic Treatment.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Relationship Between Orthodontic Malocclusion Severity and Periodontal Clinical and Biochemical Parameters in Adolescents: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orthodontic tooth movement (OTM) involves the application of mechanical forces, leading to bone remodeling through a coordinated immune response. This process comprises four stages-initial, lag, acceleration, and retention-each characterized by specific immune mechanisms involving cytokines, immune cells, and signaling pathways. Inflammatory mediators, such as interleukin (IL)-1β and tumor necrosis factor-alpha (TNF-α), initiate bone resorption, while regulatory cytokines like IL-10 promote tissue repair. The nuclear factor kappa-B ligand (RANKL)/osteoprotegerin (OPG) balance regulates osteoclast activity, ensuring controlled bone remodeling. Understanding these immune responses provides valuable insights into optimizing orthodontic treatment outcomes by controlling inflammation and enhancing therapeutic efficiency. This knowledge is significant for alleviating pain during orthodontic treatment, reducing excessive resorption of periodontal tissues, and preventing post-treatment relapse.
Indexed as
Identifiers
41225117What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.