Evidence map›Paper›PMID 41225034›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

A multicenter prospective matched comparative study on osteoporosis risk in cancer patients receiving chemotherapy.

Sabin Goktas Aydin, Ahmet Aydin, Burcin Cakan Demirel, Ozden Demir, Ayberk Bayramgil, Ozlem Kutlu, Cigdem Yildirim, Asude Aksoy, Ilkay Gulturk, Halil Taskaynatan and 2 more

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sabin Goktas AydinDepartment of Medical Oncology, SBU Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey. drsabingoktas@gmail.com.ORCID http://orcid.org/0000-0002-0077-6971
Ahmet AydinDepartment of Internal Medicine, Istanbul Medipol University, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-8610-768X
Burcin Cakan DemirelDepartment of Medical Oncology, SBU Bagcilar Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-0734-0692
Ozden DemirDepartment of Medical Oncology, Elazig Fethi Sekin Sehir Hospital, Elazig, Turkey.ORCID http://orcid.org/0000-0002-7705-7027
Ayberk BayramgilDepartment of Medical Oncology, SBU Umraniye Training and Research Hospital, Umraniye, Turkey.ORCID http://orcid.org/0000-0003-1782-7808
Ozlem KutluDepartment of Medical Oncology, Izmir Sehir Hastanesi, Izmir, Turkey.ORCID http://orcid.org/0000-0001-5050-3333
Cigdem YildirimDepartment of Medical Oncology, SBU Istanbul Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-9439-5941
Asude AksoyDepartment of Medical Oncology, Elazig Fethi Sekin Sehir Hospital, Elazig, Turkey.ORCID http://orcid.org/0000-0002-5609-9658
Ilkay GulturkDepartment of Medical Oncology, SBU Istanbul Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-1998-3150
Halil TaskaynatanDepartment of Medical Oncology, Izmir Sehir Hastanesi, Izmir, Turkey.ORCID http://orcid.org/0000-0002-3671-6540
Elif Senocak TasciDepartment of Medical Oncology, SBU Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.ORCID http://orcid.org/0000-0002-1686-1628
Caglar KoseogluDepartment of Medical Oncology, Gaziantep Şehir Hastanesi, Istanbul, Turkey.ORCID http://orcid.org/0000-0001-6870-1004

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChemotherapy and cancer can worsen osteoporosis, a growing concern with improved cancer survival rates. This study aimed to assess osteoporosis risk in chemotherapy patients versus healthy individuals and identify predictive factors.

methodsThis multicenter prospective, cross-sectional study included 257 chemotherapy-treated cancer patients and 257 age- and gender-matched controls (1:1) using propensity score matching. Exclusions included recent alcohol use, severe organ impairments, endocrine disorders, specific treatments (estrogen, progesterone, glucocorticoids, bisphosphonates, calcium supplements), and cancer-related bone conditions. Bone mineral density (BMD) at the femur and lumbar spine was measured via DXA.

resultsThe study included 174 females and 83 males (median age 59) in both groups. Of cancer patients, 37.0% had osteopenia and 21.0% had osteoporosis in lumbar vertebrae, compared to 16.3% and 2.3% in controls (p < 0.001). For total femur, 32.3% had osteopenia and 5.8% had osteoporosis in cancer patients, versus 18.7% and 1.2% in controls (p < 0.001). Median lumbar BMD was 0.90 g/cm

conclusionAddressing bone health in cancer patients is crucial for improving quality of life and reducing osteoporosis burdens.

Indexed as

Antineoplastic AgentsNeoplasmsOsteoporosisAbsorptiometry, PhotonAdultAgedBone DensityBone Diseases, MetabolicCase-Control StudiesCross-Sectional StudiesFemaleHumansLumbar VertebraeMaleMiddle AgedPropensity ScoreAntineoplastic AgentsBone healthCancerChemotherapyChemotherapy-induced osteoporosisOsteopenia

Identifiers

PMID41225034

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.