Evidence map›Paper›PMID 41225012›Full record

ArticleNature2025

Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Casey B Roos, S Luke Schulert, Lara E Zetzsche, Spencer E McMinn, Angela E Cheong, Eunjae Shim, Eugene E Kwan, Alison R H Narayan

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Installing Axial Chirality by Atroposelective C(spJournal of the American Chemical Society · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Casey B Roos *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
S Luke Schulert *Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0009-0000-5992-9410
Lara E ZetzscheLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1644-7769
Spencer E McMinnProcess Research and Development, Merck & Co., Inc., Rahway, NJ, USA.
Angela E CheongLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Eunjae ShimLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4085-9659
Eugene E KwanProcess Research and Development, Merck & Co., Inc., Rahway, NJ, USA.ORCID http://orcid.org/0000-0001-7037-0531
Alison R H NarayanLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA. arhardin@umich.edu.ORCID http://orcid.org/0000-0001-8290-0077

Funding

Biocatalytic Enantioselective Synthesis of Non-Biaryl and Hetero-Biaryl Atropisomers and Testing of their Antimalarial PropertiesF32GM147938 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROOS, CASEY BARD · 2022 to 2023
$114k
Biocatalytic generation of bioactive biaryl natural productsF31AT010973 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZETZSCHE, LARA EMILY · 2020 to 2022
$81k
NCCIH NIH HHS F31 AT010973NIGMS NIH HHS F32 GM147938
6 · The paper itself

Abstract

The synthesis of enantiopure materials is vital for pharmaceutical and agrochemical industries owing to the inherently chiral nature of biological systems and the fact that two enantiomers can have markedly different biochemical properties

Indexed as

BiocatalysisChemistry Techniques, SyntheticCytochrome P-450 Enzyme SystemNaphtholsModels, MolecularStereoisomerismCytochrome P-450 Enzyme SystemNaphthols

Identifiers

PMID41225012
PMCPMC12629982

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.