ArticleNature2026
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
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In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- NLRX1 emerges as the only observed essential regulator of the mPTP, challenging mPTP inhibition as a valid target of cardioprotection.Basic research in cardiology · 2026Review
- Ubiquitination-mediated degradation of NLRX1 drives metabolic vulnerability and accelerates intervertebral disc degeneration.Cell death and differentiation · 2026Article
- Mitochondrial superoxide-induced mitohormesis is mediated by citrate and cardioprotective.Science advances · 2026Article
- Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance.Redox biology · 2026Review
- Precision metabolic therapy for propionic acidemia.Biochemical pharmacology · 2026Review
- Regulation and roles of mammalian mitophagy.Nature reviews. Molecular cell biology · 2026Review
- Cancer drug response and resistance: molecular mechanisms and combating strategies.Signal transduction and targeted therapy · 2026Review
- The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.Nature communications · 2026Article
- New Functions of Mitochondrial Dysfunction in Gastric Cancer: From Molecular Processes to Potential Treatments.International journal of molecular sciences · 2026Review
- Mitochondrial Quality Control in Age-Related Diseases: From Molecular Architecture to Precision Therapeutics.Antioxidants (Basel, Switzerland) · 2026Review
- Lysosomes contribute to the synthesis of tricarboxylic acid-related metabolites in the hippocampus.Life metabolism · 2026Article
- Metabolic Crosstalk Between Host and Tumor as a Circuit of Resilience in Cancer Therapy.Cells · 2026Review
- Article
- Cytosolic acetyl-CoA: a metabolic regulator of mitophagy.Life metabolism · 2026Article
- Function and regulation of the mitochondrial stress response.Nature structural & molecular biology · 2026Review
- Review
- IntegratingFrontiers in immunology · 2026Review
- CAF-derived BHB modulates FXR1-Kbhb and NK-cell lipid metabolism in osteosarcoma.International journal of biological sciences · 2026Article
- Unraveling autophagy-metabolism crosstalk in cancer: Molecular insights and therapeutic strategies.Theranostics · 2026Review
- Modulation of mitochondrial quality control in sepsis by traditional Chinese medicine: mechanistic insights and translational perspectives.Frontiers in pharmacology · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Yifan Zhang *Fudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-9314-6353
Xiao Shen *Fudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Yuan Shen *Fudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Chao Wang *Fudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Chengping YuFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Jiangxue HanFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Siyi CaoFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Lin QianFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Miaolian MaNational Key Laboratory of Plant Molecular Genetics, Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0009-0007-0085-956X
Shijing HuangDepartment of Neurosurgery, Huashan Hospital, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, National Center for Neurological Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Wenyu WenDepartment of Neurosurgery, Huashan Hospital, the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, State Key Laboratory of Brain Function and Disorders and MOE Frontiers Center for Brain Science, National Center for Neurological Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID 0000-0002-0798-4730
Miao YinFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China.ORCID 0000-0001-7026-7067
Qun-Ying LeiFudan University Shanghai Cancer Center & School of Basic Medical Sciences & Institutes of Biomedical Sciences; Cancer Institutes; Key Laboratory of Breast Cancer in Shanghai; Shanghai Key Laboratory of Radiation Oncology; The Shanghai Key Laboratory of Medical Epigenetics; State Key Laboratory of Brain Function and Disorders, School of Basic Medical Sciences, Fudan University, Shanghai, China. qlei@fudan.edu.cn.ORCID 0000-0002-8547-8518
Funding
National Metabolomics Data Repository - nextgen Metabolomics WorkbenchU2CDK119886 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2018 to 2021
$12.7MBiomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2MNIDDK NIH HHS U2C DK119886NIH HHS OT2 OD030544
Abstract
Acetyl-coenzyme A (AcCoA) sits at the nexus of nutrient metabolism and shuttles between the canonical and non-canonical tricarboxylic acid cycle
Indexed as
Acetyl Coenzyme ACytosolMitophagySignal TransductionAnimalsATP Citrate (pro-S)-LyaseHumansMaleMiceMitochondriaMitochondrial ProteinsProtein DomainsAcetyl Coenzyme AATP Citrate (pro-S)-LyaseMitochondrial ProteinsNLRX1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.