ArticleNature2026
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder.Human genetics · 2026Pooled it
- Lipid flip-flop in biological membranes: through the lens of TMEM16F.Physiological reviews · 2026Review
- A comprehensive survey of genetic variants in neuroblastoma.Journal, genetic engineering & biotechnology · 2026Article
- Potential for Genomics to Help Guide Preventive Strategies in Psychiatry.JAMA psychiatry · 2026Article
- Deciphering the Role of LNX2 as a Potential Contributor to Neurodevelopmental Disorders.Genes · 2026Article
- A comprehensive overview of the biological foundations of ADHD.Bioscience reports · 2026Review
- Review
- Linking rare variants to cell-type function in profound autism with brain transcriptomics and foundation models.Cell genomics · 2026Review
- The effects of omega-3 fatty acids on Wnt activity in iPSC-derived neural stem cells from adult ADHD patients.Neuroscience applied · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors.
Ditte Demontis *Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark. ditte@biomed.au.dk.ORCID 0000-0001-9124-2766
Jinjie Duan *Department of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3402-302X
Yu-Han H HsuNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-4063-0552
Greta PintacudaNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5126-2279
Jakob GroveDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-2284-5744
Trine Tollerup NielsenDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
Janne ThirstrupDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
Makayla MartoranaNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Travis BottsNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0009-0001-6725-7543
F Kyle SatterstromStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6187-7680
Jonas Bybjerg-GrauholmLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.ORCID 0000-0003-1705-4008
Jason H Y TsaiDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.
Simon GlerupDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-9686-8124
Martine HoogmanDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Jan BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0001-8288-7757
Marieke KleinDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0001-8784-5679
Georg C ZieglerDepartment of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0001-9411-3169
Christian JacobDepartment of Psychiatry and Psychotherapy, Medius Hospital of Kirchheim, Kirchheim unter Teck, Germany.
Oliver GrimmDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Maximilian BayasDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Nene F KobayashiDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Sarah Kittel-SchneiderDepartment of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
Klaus-Peter LeschDivision of Molecular Psychiatry, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.ORCID 0000-0001-8348-153X
Barbara FrankeDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.ORCID 0000-0003-4375-6572
Andreas ReifDepartment of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-0992-634X
Esben AgerboLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.ORCID 0000-0002-2849-524X
Thomas WergeLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.ORCID 0000-0003-1829-0766
Merete NordentoftLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
Ole MorsLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
Preben Bo MortensenLundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
Kasper LageNovo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6827-6239
Mark J DalyStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0949-8752
Benjamin M NealeStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-1513-6077
Anders D BørglumDepartment of Biomedicine-Human Genetics, Aarhus University, Aarhus, Denmark. anders@biomed.au.dk.ORCID 0000-0001-8627-7219
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M2/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124851 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI BOERGLUM, ANDERS, DAVIS, LEA K · 2021 to 2025
$5.4MLEGENNDS: Linking Epidemiology and GEnetics of Neurodevelopmental and Neurodegenerative Disorders StudyR01NS131433 · NINDS · DREXEL UNIVERSITY · PI Brian Kane Lee · 2023 to 2026
$2.1MFrom genetic risk variants to convergent protein networks: an integrative approach to elucidate the causal molecular mechanisms of schizophrenia.U01MH121499 · NIMH · BROAD INSTITUTE, INC. · PI HANSEN, KASPER LAGE · 2020 to 2020
$829kNHGRI NIH HHS U54 HG003067NIMH NIH HHS R01 MH124851NIMH NIH HHS U01 MH121499NINDS NIH HHS R01 NS131433
Abstract
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a large genetic component
Indexed as
Attention Deficit Disorder with HyperactivityGenetic Predisposition to DiseaseGenetic VariationNeuronsAdolescentAdultChildDopaminergic NeuronsExome SequencingFemaleHumansIntelligenceMaleMicrotubule-Associated ProteinsProtein Interaction MapsRisk FactorsMicrotubule-Associated Proteins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.