Evidence map›Paper›PMID 41224995›Full record

ArticleNature2026

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion.

Fengxiang Wang, Cuiji Sun, Tianshu William Wu, Yuting Fu, Yujing Fan, Shuchang Zhao, Kaiyin Huang, Zijian Pan, Yang Lu, Jingrong Regina Han and 18 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Thousandfold Expansion Microscopy.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. An update on spatial proteomics.Nature methods · 2026
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Fengxiang Wang *Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.ORCID 0000-0003-1687-3466
Cuiji Sun *Research Center for the Industries of the Future, Westlake University, Hangzhou, China.ORCID 0009-0009-8446-3849
Tianshu William Wu *Westlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.ORCID 0000-0001-5359-6221
Yuting FuResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.
Yujing FanWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Shuchang ZhaoResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.
Kaiyin HuangWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.ORCID 0000-0002-9991-0404
Zijian PanWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Yang LuWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Jingrong Regina HanWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Shikai JiaResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.
Lizhou ZengWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Sheng ZhangSchool of Life Sciences, Westlake University, Hangzhou, China.
Ting ChenSchool of Life Sciences, Westlake University, Hangzhou, China.
Shaowei AnSchool of Life Sciences, Westlake University, Hangzhou, China.
Shuang Susie MengWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xun GuoResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.
Weizhe LiSchool of Life Sciences, Westlake University, Hangzhou, China.
Heyuan LianWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xiaoting SunResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.
Jin HuMass Spectrometry and Metabolomics Core Facility, Westlake University, Hangzhou, China.
Chuanzhen YangWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Shan FengMass Spectrometry and Metabolomics Core Facility, Westlake University, Hangzhou, China.ORCID 0000-0001-6474-4429
Pengfei LiBruker (Beijing) Scientific Technology, Beijing, China.
Liyuan DuCreate (Beijing) Technology, Beijing, China.
Xiaodong LiuResearch Center for the Industries of the Future, Westlake University, Hangzhou, China.ORCID 0000-0002-9315-3406
Kiryl D PiatkevichResearch Center for the Industries of the Future, Westlake University, Hangzhou, China. kiryl.piatkevich@westlake.edu.cn.ORCID 0000-0002-7777-9468
Yilong ZouWestlake Four-Dimensional Dynamic Metabolomics (Meta4D) Laboratory, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. zouyilong@westlake.edu.cn.ORCID 0000-0001-8198-6067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The number of spatial omics technologies being developed is increasing

Indexed as

ProteomicsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAlzheimer DiseaseAnimalsBrainFemaleHumansLiverMaleMiceMitochondriaOrganoidsRetina

Identifiers

PMID41224995

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.