Evidence map›Paper›PMID 41224993›Full record

ArticleNature2025

In situ structural mechanism of epothilone-B-induced CNS axon regeneration.

Satish Bodakuntla, Kenichiro Taira, Yurika Yamada, Pelayo Alvarez-Brecht, A King Cada, Nirakar Basnet, Rui Zhang, Antonio Martinez-Sanchez, Christian Biertümpfel, Naoko Mizuno

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Satish Bodakuntla *Laboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Kenichiro Taira *Laboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Yurika YamadaLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Pelayo Alvarez-BrechtLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
A King CadaLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9284-0941
Nirakar BasnetLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Rui ZhangDepartment of Biochemistry and Molecular Biophysics, School of Medicine, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3159-9565
Antonio Martinez-SanchezDepartment of Information and Communications Engineering, Faculty of Computer Science, University of Murcia, Murcia, Spain.ORCID 0000-0002-5865-2138
Christian BiertümpfelLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7528-6547
Naoko MizunoLaboratory of Structural Cell Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Naoko.mizuno@nih.gov.ORCID 0000-0002-1594-2821

Funding

Molecular organization of pathways governing cell-shape formationZIAHL006264 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MIZUNO, NAOKO · 2021 to 2025
$11.6M
Intramural NIH HHS ZIA HL006264
6 · The paper itself

Abstract

Axons in the adult central nervous system (CNS) do not regenerate following injury, in contrast to neurons in the peripheral nervous system and neuronal growth during embryonic development. The molecular mechanisms that prevent regeneration of neurons in the CNS remain largely unknown

Indexed as

AxonsEpothilonesNerve RegenerationAnimalsCell MembraneCryoelectron MicroscopyElectron Microscope TomographyEndoplasmic ReticulumFemaleHomeostasisMiceMicrotubulesRatsTubulinepothilone BEpothilonesTubulin

Identifiers

PMID41224993
PMCPMC12795760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.