Evidence map›Paper›PMID 41224969›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Psychedelics produce enduring behavioral effects and functional plasticity through mechanisms independent of structural plasticity.

Hannah M Kramer, Meghan Hibicke, Jason Middleton, Alaina M Jaster, Jesper L Kristensen, Charles D Nichols

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. The entropic brain today.Brain : a journal of neurology · 2026
    Review
  2. Article
  3. The working lives of neuronal 5-HTRSC chemical biology · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah M Kramer *Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.
Meghan Hibicke *Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.ORCID http://orcid.org/0000-0002-9394-9789
Jason MiddletonDepartment of Cell Biology and Anatomy, LSU Health Sciences Center, New Orleans, LA, USA.
Alaina M JasterDepartment of Psychiatry and Behavioral Neuroscience, Wayne State University, Detroit, MI, USA.
Jesper L KristensenDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen Ø, Denmark.
Charles D NicholsDepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA. cnich1@lsuhsc.edu.ORCID http://orcid.org/0000-0002-0615-0646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of serotonin 2A (5-HT

Indexed as

Behavior, AnimalHallucinogensNeuronal PlasticityPrefrontal CortexPsilocybinSerotonin 5-HT2 Receptor AgonistsAnimalsMaleRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2AHallucinogensPsilocybinReceptor, Serotonin, 5-HT2ASerotonin 5-HT2 Receptor Agonists

Identifiers

PMID41224969
PMCPMC12824308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.