Evidence map›Paper›PMID 41224901›Full record

ArticleNature chemistry2026

Stereodivergent construction of non-adjacent stereocentres via migratory functionalization of alkenes.

Guodong Ju, Xueyuan Yan, Haohao Bai, Mengyuan Liu, Xinping Xi, Yi Liu, Genping Huang, Chao Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Transforming Molecular Synthesis With Large Language Models.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guodong Ju *Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.ORCID http://orcid.org/0009-0007-1744-7385
Xueyuan Yan *Department of Chemistry, School of Science, Tianjin University, Tianjin, China.ORCID http://orcid.org/0009-0007-7154-8902
Haohao BaiTianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.
Mengyuan LiuTianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.
Xinping XiTianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.
Yi LiuTianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China.
Genping HuangDepartment of Chemistry, School of Science, Tianjin University, Tianjin, China. gphuang@tju.edu.cn.ORCID http://orcid.org/0000-0002-2249-1248
Chao WangTianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin, China. chwang@tjnu.edu.cn.ORCID http://orcid.org/0000-0001-6979-8506

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21901185National Natural Science Foundation of China (National Science Foundation of China) 22073066National Natural Science Foundation of China (National Science Foundation of China) 22471191Natural Science Foundation of Tianjin City (Natural Science Foundation of Tianjin) 23JCYBJC00760
6 · The paper itself

Abstract

Stereodivergent construction of multiple stereocentres is one of the most essential tasks in asymmetric synthesis. However, strategies for assembling all possible stereoisomers of optically active compounds bearing non-adjacent stereocentres remain scarce and suffer from certain limitations in terms of reaction types and chemical space. Here we succeed in utilizing the chain walking strategy to realize the simultaneous construction of acyclic 1,n-non-adjacent (n = 3 or 4) stereocentres via Ni-catalysed migratory hydroalkylation of trisubstituted alkenes in an enantioselective and diastereodivergent manner. A series of alkyl units can be site-selectively installed at α-C(sp

Identifiers

PMID41224901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.