Evidence map›Paper›PMID 41224899›Full record

ArticleScientific reports2025

The zinc bound form of the actinomycete derived natural product compound JBIR-141 induces a mitotic phenotype in fission yeast.

Richard Alexander Lewis, Jacqueline Hayles, Michael John Hall, Joe Gray, Sofanit Mebrate, Juanjuan Li, Nicholas Edward Ellis Allenby, Jeff Errington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Richard Alexander LewisDemuris Ltd/Odyssey Therapeutics, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK. r.lewis@axitan.com.
Jacqueline HaylesCell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Michael John HallChemistry, School of Environmental and Natural Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Joe GrayPinnacle Laboratory, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Sofanit MebrateCell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Juanjuan LiUniversity of Southampton, University Road, Southampton, SO17 1AT, UK.
Nicholas Edward Ellis AllenbyDemuris Ltd/Odyssey Therapeutics, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.
Jeff ErringtonDemuris Ltd/Odyssey Therapeutics, The Biosphere, Draymans Way, Newcastle Helix, Newcastle upon Tyne, NE4 5BX, UK.

Funding

ARC Australian Laureate Fellowship FL210100071
6 · The paper itself

Abstract

This study was designed to identify the natural product compound produced by the actinomycete strain "S149" which is capable of inducing a strong small cell phenotype, called wee, in the fission yeast Schizosaccharomyces pombe. We purified the bioactive molecule, which, on the basis of mass spectrometry data, was identified as a novel zinc-bound form of the previously published molecule JBIR-141. JBIR-141 was not previously known to be a zincophore and does not possess structural features common to other bacterial zinc-binding natural product compounds. Testing the effect of the Zn

Indexed as

Biological ProductsMitosisSchizosaccharomycesZincPhenotypeSchizosaccharomyces pombe ProteinsBiological ProductsSchizosaccharomyces pombe ProteinsZincFission yeastJBIR-141Pyp1ZincZincophore

Identifiers

PMID41224899
PMCPMC12612195

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.