Evidence map›Paper›PMID 41224757›Full record

ArticleNature communications2025

Age-impaired remyelination is associated with dysregulated microglial transitions.

Sameera Zia, Marianela E Traetta, Charbel S Baaklini, Brady P Hammond, Rebecca K John, Katherine M Souter, Niels Meijns, Larry K A Afun, Sharmistha Panda, Fernando González Ibáñez and 27 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Sameera ZiaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Marianela E TraettaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Charbel S BaakliniNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-1075-0767
Brady P HammondNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Rebecca K JohnNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Katherine M SouterNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-3136-263X
Niels MeijnsDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam, The Netherlands.
Larry K A AfunNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Sharmistha PandaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Fernando González IbáñezDivision of Medical Sciences, University of Victoria, Victoria, BC, Canada.ORCID http://orcid.org/0000-0003-3330-437X
Mena K BurrNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Eva DhupiaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Abhisha M RathodNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Andre O FariaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Dhruvish ZaveriNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Sowmya ChallaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Eugene HahnNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Sohrab B ManeshDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada.
Kelly V LeeNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Madelene F S HoNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Timothy N FriedmanNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-0058-5075
Aislinn D MaguireNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Arina PangNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0009-0008-4382-0224
Olivia FarkasNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Bożena SzulcNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-7782-9592
Luiz TenorioDepartment of Anesthesiology and Pain Medicine, University of Alberta, Edmonton, AB, Canada.
Diya VyasNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Olivia R La CapraraNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Wolfram TetzlaffInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Sarthak SinhaDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-0770-3150
Gregory J DuncanInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0003-0203-9972
Anastassia VoronovaNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0001-7504-1905
Bradley J KerrNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada.
Marie-Eve TremblayDivision of Medical Sciences, University of Victoria, Victoria, BC, Canada.ORCID http://orcid.org/0000-0003-2863-9626
Jeff BiernaskieDepartment of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0002-0633-0698
Geert SchenkDepartment of Anatomy and Neurosciences, Amsterdam University Medical Center, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam, The Netherlands.
Jason R PlemelNeuroscience and Mental Health Institute, University of Alberta, Edmonton, AB, Canada. jrplemel@ualberta.ca.ORCID http://orcid.org/0000-0003-1385-1464

Funding

National Multiple Sclerosis Society (National MS Society) NMSS PRG PP-1912-35420U.S. Department of Defense (United States Department of Defense) W81XWH-21-1-0797
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic, inflammatory condition characterized by neurodegeneration and lost myelin, or demyelination. This lost myelin may be regenerated in people with MS through a process called remyelination, that is prone to failure and is impaired with age. Remyelination is facilitated by microglia but our understanding of the microglial response during remyelination is incomplete. Here, we profile the microglial response during remyelination in the lysolecithin mouse model using single-cell RNA sequencing and find several distinct microglial states during the early stages of remyelination that coalesce into a resolved state defined by the presence of myelin transcripts, a state also present in MS brains. We also observe a delay in the appearance of several microglial states with age, in concordance with delayed remyelination. This multi-faceted microglial response during efficient remyelination provides the basis of multi-faceted microglia-specific targets for future MS therapies.

Indexed as

AgingMicrogliaMultiple SclerosisMyelin SheathRemyelinationAnimalsBrainDemyelinating DiseasesDisease Models, AnimalFemaleHumansLysophosphatidylcholinesMaleMiceMice, Inbred C57BLSingle-Cell AnalysisLysophosphatidylcholines

Identifiers

PMID41224757
PMCPMC12612223

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.