ArticleNature communications2025
Nickel-catalyzed arylative telomerization of isoprene.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Palladium-Catalyzed Regiodivergent Telomerization of Isoprene With Oxindoles.Angewandte Chemie (International ed. in English) · 2026Article
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Authors and funding
7 authors.
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Abstract
Developing new transformations of bulky chemicals is an important approach to expand the reaction boundary of current chemistry. Instead of traditional hydroarylation of dienes, we herein demonstrate a nickel-catalyzed arylative telomerization of isoprene with high chemo- and regioselectivities. By utilizing a bulky mono-phosphine ligand, a range of structurally diverse aryl substituted terpenes are created efficiently under redox-neutral conditions. Preliminary mechanistic studies suggest this telomerization proceeds through an oxidative cyclometallation of isoprene with Ni(0) species followed by arylation with organoboron reagents. Beyond enabling efficient isoprene transformation, this work also provides a supplementary approach for the monoterpenoids synthesis.
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Registered trials
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