Evidence map›Paper›PMID 41224731›Full record

ArticleJournal of applied clinical medical physics2025

Automatic radiotherapy planning for deliverable plans using deep learning dose prediction and dose rings optimization in cervical cancer.

Weiqian Huang, Ting Liu, Yichao Shen, Ziqing Xiang, Dong Wang, Wen Fu, Li Shao, Xianwen Yu, Weihua Ni, Yongqiang Zhou and 4 more

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weiqian Huang
Ting LiuThe 1st School of Medicine (School of information and Engineering), Wenzhou Medical University, Zhejiang, China.
Yichao ShenDepartment of Radiation Oncology, Taizhou Hospital, Taizhou, China.
Ziqing XiangDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Dong WangDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wen FuDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Li ShaoDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xianwen YuDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Weihua NiDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yongqiang ZhouDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Huan LiuDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Ce HanDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiance JinDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-4117-5953
Ji ZhangDepartment of Radiotherapy and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Funding

Key project of Zhejiang Provincial Health Science and Technology Program WKJ-ZJ-2437Major project of Wenzhou Science and Technology Bureau ZY2020011Major project of Wenzhou Science and Technology Bureau ZY2022016Project of Wenzhou Science and Technology Bureau Y20240192Project Supported by Scientific Research Fund of Zhejiang Provincial Education Department Y202352935Zhejiang Natural Science Foundation LZ24A050008
6 · The paper itself

Abstract

backgroundAutomatic radiotherapy (RT) planning based on deep learning (DL) has been extensively researched. However, it is challenging to import the predicted dose distribution into mainstream treatment planning systems (TPSs) and generate clinically deliverable plans. PURPOSE: To investigate the feasibility and accuracy of an automatic volumetric modulated arc therapy (VMAT) and intensity-modulated radiation therapy (IMRT) planning method for generation of universally deliverable plans based on DL dose prediction and dose rings optimization.

methodsFirst, dose distributions were predicted using a three-dimensional (3D) Fusion Residual Unet (F-ResUnet) DL network with data from two hospitals, which included 230 and 210 gynecological cancer (GC) patients underwent VMAT and IMRT, respectively. Then, the predicted dose distributions were discretized into dose rings to optimize the plans automatically in two mainstream TPSs based on the dose rings. Finally, the deliverability of generated plans was verified with patient-specific quality assurance (PSQA).

resultsThe predicted dose distributions were clinically acceptable with a target coverage over 95%. Compared with the clinical plans, the automatic plans optimized with dose rings achieved a similar dose coverage on planning target volumes (PTV) with an average target coverage over 96.5%. For organs at risk (OARs) sparing, automatic VMAT plans markedly decreased the V

conclusionsThe proposed automatic planning method combining DL dose prediction and dose rings optimization was feasible to generate universally deliverable VMAT and IMRT plans for gynecological cancer (GC) patients.

Indexed as

Deep LearningOrgans at RiskRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedUterine Cervical NeoplasmsFemaleHumansQuality Assurance, Health CareRadiotherapy Dosageautomatic planningdeep learningdose rings optimizationintensity‐modulated radiation therapyvolumetric modulated arc therapy

Identifiers

PMID41224731
PMCPMC12611595

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.