ArticleAnnals of Indian Academy of Neurology2025
A Study of the Association of Cerebrospinal Fluid Neutrophil-to-Lymphocyte Ratio with Severity and Mortality in Patients with Tuberculous Meningitis.
Article in Annals of Indian Academy of Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Immune-inflammatory profiles and disease severity in pulmonary tuberculosis complicated by central nervous system tuberculosis.Frontiers in cellular and infection microbiology · 2026Article
- Age-Stratified Effects of Diabetes Mellitus on Central Nervous System Tuberculosis Risk and Combined Effects with Neutrophil-to-Lymphocyte Ratio.Infection and drug resistance · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing severity of tuberculous meningitis (TBM) carries a poor prognosis. This study aimed to correlate cerebrospinal fluid (CSF)-neutrophil-lymphocyte ratio (NLR) with TBM severity and assess its ability to predict in-hospital mortality. A prospective observational study was conducted from February 2023 to February 2025, enrolling 148 confirmed cases of TBM. The severity of TBM was graded according to the British modified Medical Research Council criteria. The mean age was 38.0 ± 17.6 years, with 69 males and 79 females. Of these, 47 had grade 1, 67 had grade 2, and 34 had grade 3 severity of TBM. The CSF-NLR ratio showed no significant correlation (r = 0.113, P = 0.170) with TBM severity. Thirty-three patients died; among them, 27 had low CSF-NLR (≤0.82), while six had high CSF-NLR (>0.82). A CSF-NLR cut-off value of 0.82 had a diagnostic accuracy of 39.19% (sensitivity 81.82%, specificity 26.96%) for predicting mortality. The results negate the use of CSF-NLR as a diagnostic marker for grading TBM severity or predicting mortality.
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