SynthesisThe Journal of international medical research2025
Oral contraceptives and the risk of rheumatoid arthritis in women: A systematic review and meta-analysis.
Synthesis in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectivesThe relationship between the use of oral contraceptives and the risk of rheumatoid arthritis remains unclear. The objective of this meta-analysis was to comprehensively evaluate the association between oral contraceptive use and rheumatoid arthritis risk.MethodsA systematic search was conducted in PubMed, EMBASE, and Cochrane Library databases for cohort studies published from 1980 to July 2024. Studies were assessed for bias using the Newcastle-Ottawa Scale. Two investigators independently screened abstracts and full-text articles and graded the certainty of evidence according to the Grading of Recommendations Assessment, Development and Evaluation approach. Data were analyzed using random effects models, and publication bias was evaluated using funnel plots and Egger test. A leave-one-out sensitivity analysis was performed, which demonstrated the robustness of the overall pooled estimate.ResultsTwelve cohort studies (1989-2024) with 1,126,554 participants were included. There was no significant overall association between oral contraceptive use and rheumatoid arthritis risk (relative risk = 0.96, 95% confidence interval: 0.93-1.00,
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