ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
Anxiety and Beyond: Diversity in Ventral Hippocampus Circuits and Function.
Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus.Frontiers in molecular neuroscience · 2026Article
- The 'hand-brain-emotion' axis: a theoretical model for handicraft art-based intervention in anxiety disorders through neuroplasticity and autonomic regulation.Frontiers in psychology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The ventral hippocampus (vHPC), initially implicated in anxiety regulation, is now recognized for its broader role in integrating emotional, motivational, and contextual information. This review synthesizes recent insights from rodent research presented at our 2025 Society for Neuroscience minisymposium, detailing how local inhibitory microcircuits, long-range projection-defined pathways, and neuromodulatory inputs interact to shape fear, anxiety, and reward behaviors. We emphasize how distinct circuits segregate fear and anxiety, resolve approach-avoidance conflicts, and integrate reward history. Serotonergic modulation, particularly from the median raphe, emerges as a critical regulator of vHPC dynamics, with pronounced sex-specific functional implications. Finally, we examine how vCA1 ensemble activity encodes emotionally salient stimuli and supports latent state inference, thereby enabling flexible decision-making under uncertainty. Collectively, these findings recast the vHPC as a modular, computationally rich structure essential for adaptive behavior, which may provide new insights into circuit-level dysfunction in affective disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.